Respiratory complications of propofol, sevoflurane, and dexmedetomidine anesthesia for fiberoptic bronchoscopy in children aged 1 month to 3 years: a randomized trial

To evaluate the effect of propofol, sevoflurane, and dexmedetomidine on respiratory complications in children undergoing fiberoptic bronchoscopy (FOB). This double-blind randomized clinical trial was conducted among 120 children aged 1 month to 3 years undergoing FOB. The patients were randomized in...

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Bibliographic Details
Published in:Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2024-09, Vol.44 (9), p.1631
Main Authors: Amir, Shafa, Mohammad, Montasery, Sedighe, Shahhosseini, Majid, Keivanfar, Asieh, Maghami Mehr, Mahtab, Ebrahim Babaei, Mohammad, Jafari
Format: Article
Language:Chinese
Subjects:
Anesthetics, Inhalation - adverse effects
Bronchoscopy - adverse effects
Bronchoscopy - methods
Child, Preschool
Cough
Dexmedetomidine - adverse effects
Double-Blind Method
Female
Humans
Hypnotics and Sedatives - administration & dosage
Hypnotics and Sedatives - adverse effects
Infant
Male
Methyl Ethers - administration & dosage
Methyl Ethers - adverse effects
Propofol - administration & dosage
Propofol - adverse effects
Sevoflurane - administration & dosage
Sevoflurane - adverse effects
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Summary:To evaluate the effect of propofol, sevoflurane, and dexmedetomidine on respiratory complications in children undergoing fiberoptic bronchoscopy (FOB). This double-blind randomized clinical trial was conducted among 120 children aged 1 month to 3 years undergoing FOB. The patients were randomized into 3 groups ( =40) for anesthesia induction with sevoflurane inhalation, 1 mg/kg propofol, or 1 μg/kg dexmedetomidine before bronchoscopy, and the changes in hemodynamic parameters, sedation level, and respiratory complications during and after the procedure were assessed. The patients' heart rate during bronchoscopy was significantly lower and the mean arterial blood pressure significantly higher in dexmedetomidine group than in sevoflurane and propofol groups ( < 0.05). Cough during bronchoscopy did not occur in any of the cases in propofol group, while the highest frequency of cough was recorded in dexmedetomidine group. The incidence of laryngospasm in the propofol group (12.5%) was significantly lower than tho
ISSN:1673-4254
DOI:10.12122/j.issn.1673-4254.2024.09.01