Effect of body mass index on immune checkpoint inhibitor efficacy in patients with advanced cancer

Background: The need for predictive factors regarding the response to immune checkpoint inhibitors (ICIs) is increasing. Recent research indicates that an enhanced response to ICIs is associated with a higher body mass index (BMI). This study aims to evaluate the relationship between response to ICI...

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Bibliographic Details
Published in:Tumori 2024-12, Vol.110 (6), p.437-442
Main Authors: Alkan Şen, Gülin, Şentürk Öztaş, Nihan, Değerli, Ezgi, Guliyev, Murad, Turna, Hande, Özgüroğlu, Mustafa
Format: Article
Language:English
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Summary:Background: The need for predictive factors regarding the response to immune checkpoint inhibitors (ICIs) is increasing. Recent research indicates that an enhanced response to ICIs is associated with a higher body mass index (BMI). This study aims to evaluate the relationship between response to ICIs and BMI in solid tumors. Methods: We retrospectively analyzed patients with advanced cancer treated with ICIs at one academic center. We compared the treatment responses of patients classified as underweight/normal weight (BMI
ISSN:0300-8916
2038-2529
2038-2529
DOI:10.1177/03008916241291989