Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology

INTRODUCTION Factors responsible for the deposition of pathological tau in the brain are incompletely understood. This study links macroscale tau deposition in the human brain to cerebrospinal fluid (CSF) flow dynamics using resting‐state functional magnetic resonance imaging (rsfMRI). METHODS Low‐f...

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Bibliographic Details
Published in:Alzheimer's & dementia 2024-12, Vol.20 (12), p.8541-8555
Main Authors: Han, Feng, Lee, JiaQie, Chen, Xi, Ziontz, Jacob, Ward, Tyler, Landau, Susan M., Baker, Suzanne L., Harrison, Theresa M., Jagust, William J.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer Disease - cerebrospinal fluid
Alzheimer Disease - diagnostic imaging
Alzheimer Disease - physiopathology
Alzheimer's disease pathology
Amyloid beta-Peptides - cerebrospinal fluid
Brain - diagnostic imaging
Brain - pathology
brain atrophy
cerebrospinal fluid (CSF) flow
Cerebrospinal Fluid - physiology
Cognitive Dysfunction - cerebrospinal fluid
Cognitive Dysfunction - physiopathology
CSF dynamics‐related clearance
Female
global resting‐state fMRI signal
Humans
Magnetic Resonance Imaging
Male
tau deposition
tau Proteins - cerebrospinal fluid
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Summary:INTRODUCTION Factors responsible for the deposition of pathological tau in the brain are incompletely understood. This study links macroscale tau deposition in the human brain to cerebrospinal fluid (CSF) flow dynamics using resting‐state functional magnetic resonance imaging (rsfMRI). METHODS Low‐frequency (
ISSN:1552-5260
1552-5279
1552-5279
DOI:10.1002/alz.14296