Iron(II)-Catalyzed Synthesis of Nitrated Dihydropyrazole via a Nitrification and C–H Activation/Cyclization Cascade Reaction

A route for nitrification and C–H activation/cyclization of (E)-N-allyl-N′-benzylidenebenzenesulfonohydrazide and cobalt nitrate via an iron­(II)-catalyzed cascade reaction to synthesize nitrated dihydropyrazoles has been developed. The method features convenient operation and good functional group...

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Bibliographic Details
Published in:Journal of organic chemistry 2024-11, Vol.89 (22), p.16317-16324
Main Authors: Cheng, Weibo, Zhang, Xi, Liu, Yi, Zhang, Mei, Sun, Junzheng, Liu, Changji, Yang, Wenjing, Xia, Chengcai, You, Guirong
Format: Article
Language:English
Subjects:
carbon-hydrogen bond activation
catalysts
cobalt nitrate
cyclization reactions
nitrification
organic chemistry
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Summary:A route for nitrification and C–H activation/cyclization of (E)-N-allyl-N′-benzylidenebenzenesulfonohydrazide and cobalt nitrate via an iron­(II)-catalyzed cascade reaction to synthesize nitrated dihydropyrazoles has been developed. The method features convenient operation and good functional group tolerance. In addition, it employs insensitive and inexpensive FeSO4 as the catalyst and provides a direct approach for the preparation of dihydropyrazoles.
ISSN:0022-3263
1520-6904
1520-6904
DOI:10.1021/acs.joc.4c00313