Characterization of the Molecular Signature of Human Monocytes in Aging and Myelodysplastic Neoplasms

• Aging leads to chronic inflammation and immune dysfunction, heightening the risk of myeloid malignancies like MDS and CMML. • Both aging and MDS show alterations in monocyte subtypes and function. Aging boosts inflammatory genes upregulation, whereas MDS favors antigen presentation, reflecting dis...

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Published in:European journal of immunology 2024-11, p.e202451387
Main Authors: Rimpa, Christina Maria, Grigoriou, Maria, Tasis, Athanasios, Paschalidis, Nikolaos, Filia, Anastasia, Vatsellas, Giannis, Papazoglou, Panagiotis, Chatzigeorgiou, Antonios, Kymparidou, Chrysa, Papoutselis, Menelaos, Misidou, Christina, Spyropoulos, Theodoros, Dimitriou, Despoina, Hatzikirou, Haralampos, Liapis, Konstantinos, Lamprianidou, Eleftheria, Kotsianidis, Ioannis, Mitroulis, Ioannis
Format: Article
Language:English
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Summary:• Aging leads to chronic inflammation and immune dysfunction, heightening the risk of myeloid malignancies like MDS and CMML. • Both aging and MDS show alterations in monocyte subtypes and function. Aging boosts inflammatory genes upregulation, whereas MDS favors antigen presentation, reflecting distinct immune and disease-specific adaptations. • MDS shows reduced inflammatory activity in CD14 cells, whereas CMML exhibits heightened inflammation, highlighting distinct disease mechanisms.
ISSN:0014-2980
1521-4141
1521-4141
DOI:10.1002/eji.202451387