SLCO1B1 variants in a patient of African ancestry presenting with rosuvastatin‐induced rhabdomyolysis: A case report

We report a case of an adult woman of African ancestry who was hospitalized with statin induced‐ rhabdomyolysis. The patient presented to the emergency room with a 2‐week history of worsening muscle pain, nausea, vomiting and low oral intake, 1 month after starting 40 mg daily dose of rosuvastatin....

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Bibliographic Details
Published in:British journal of clinical pharmacology 2025-01, Vol.91 (1), p.232-235
Main Authors: Medwid, Samantha, Deckert, Rowan, Gryn, Steven E., Kim, Richard B.
Format: Article
Language:English
Subjects:
Adult
Black People - genetics
Case Report
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects
Liver-Specific Organic Anion Transporter 1 - genetics
pharmacogenetics
rhabdomyolysis
Rhabdomyolysis - chemically induced
Rhabdomyolysis - diagnosis
Rhabdomyolysis - genetics
Rosuvastatin Calcium - administration & dosage
Rosuvastatin Calcium - adverse effects
SLCO1B1
statins
Citations: Items that this one cites
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Description
Summary:We report a case of an adult woman of African ancestry who was hospitalized with statin induced‐ rhabdomyolysis. The patient presented to the emergency room with a 2‐week history of worsening muscle pain, nausea, vomiting and low oral intake, 1 month after starting 40 mg daily dose of rosuvastatin. Sequencing of SLCO1B1 coding regions revealed the patient was heterozygous for two SLCO1B1 deleterious variants, c.481+1G>T and c.1463G>C (*9), which are more prevalent in patients of African ancestry. This highlights the importance of pharmacogenetic testing in SLCO1B1, which includes a broader range of genetic variants for patients of African ancestry.
ISSN:0306-5251
1365-2125
1365-2125
DOI:10.1111/bcp.16329