Magnetic resonance imaging in comatose adults resuscitated after out-of-hospital cardiac arrest: A posthoc study of the Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest trial

Neuroimaging with magnetic resonance imaging (MRI) may assist clinicians in evaluating brain injury and optimising care in comatose adults resuscitated after out-of-hospital cardiac arrest (OHCA). However, contemporary international data on its use are lacking. The primary aim was to compare the pat...

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Published in:Australian critical care 2024-11, p.101130, Article 101130
Main Authors: Eastwood, Glenn M., Bailey, Michael, Nichol, Alistair D., Dankiewicz, Josef, Nielsen, Niklas, Parke, Rachael, Cronberg, Tobias, Olasveengen, Theresa, Grejs, Anders M., Iten, Manuela, Haenggi, Matthias, McGuigan, Peter, Wagner, Franca, Moseby-Knappe, Marion, Lang, Margareta, Bellomo, Rinaldo, Hodgson, Carol, McGuinness, Shay, Bernard, Stephen, Skrifvars, Markus B., Stub, Dion, Taccone, Fabio S., Archer, John, Kutsogiannis, Demetrios, Lilja, Gisela, Kirkegaard, Hans, Capellier, Gilles, Landoni, Giovanni, Horn, Janneke, Arabi, Yaseen, Chia, Yew Woon, Markota, Andrej, Wise, Matt P., Christensen, Steffen, Munk-Andersen, Heidi, Granfeldt, Asger, Andersen, Geir Ø., Qvigstad, Eirik, Flaa, Arnljot, Thomas, Matthew, Sweet, Katie, Bewley, Jeremy, Bäcklund, Minna, Tiainen, Marjaana, Levis, Anja, Peck, Leah, Walsham, James, Deane, Adam, Ghosh, Angajendra, Annoni, Filippo, Chen, Yan, Knight, David, Lesona, Eden, Tlayjeh, Haytham, Svenšek, Franc, Cole, Jade, Pogson, David, Hilty, Matthias P., Düring, Joachim P., Paul, Eldho, Ady, Bridget, Ainscough, Kate, Hunt, Anna, Monahan, Sinéad, Trapani, Tony, Fahey, Ciara
Format: Article
Language:English
Subjects:
Magnetic resonance imaging
Mortality
Neuroprognostication
Out-of-hospital cardiac arrest
Post–cardiac arrest care
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Summary:Neuroimaging with magnetic resonance imaging (MRI) may assist clinicians in evaluating brain injury and optimising care in comatose adults resuscitated after out-of-hospital cardiac arrest (OHCA). However, contemporary international data on its use are lacking. The primary aim was to compare the patient characteristics, early postresuscitation care, and neurological outcomes of patients according to MRI use. We performed a posthoc analysis of the Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) trial, a multinational randomised trial comparing targeted mild hypercapnia or normocapnia in comatose adults after OHCA. After exclusions, 1639 patients enrolled in the TAME trial were analysed. Of these, 149 (9%) had an MRI. Compared to non-MRI patients, MRI patients were younger (58.9 versus 61.7 years, p: 0.02), had a longer median time from OHCA to return of spontaneous circulation (30 versus 25 min, p 
ISSN:1036-7314
DOI:10.1016/j.aucc.2024.09.015