Innovative anticancer nanocomposites from Corchorus olitorius mucilage/chitosan/selenium nanoparticles

Cancers are continuing to threaten human health globally; the achievement of effectual and biosafe anticancerous compounds is a precious goal. The extraction of Corchorus olitorius mucilage (Jm) and its usage for selenium nanoparticles (SeNPs) biosynthesis was projected. The innovative formulation o...

Full description

Saved in:
Bibliographic Details
Published in:International journal of biological macromolecules 2024-12, Vol.282 (Pt 5), p.137320, Article 137320
Main Authors: El-Sherbiny, Mohsen M., El-Hefnawy, Mohamed E., Tayel, Ahmed A.
Format: Article
Language:English
Subjects:
Anticancer assays
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Biopolymers
Caco-2 Cells
Cell Survival - drug effects
Chitosan - chemistry
Chitosan - pharmacology
Green synthesis
HeLa Cells
Humans
Jute mucilage
Nanocomposites - chemistry
Nanoconjugation
Nanoparticles - chemistry
Plant Mucilage - chemistry
Selenium - chemistry
Selenium - pharmacology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cancers are continuing to threaten human health globally; the achievement of effectual and biosafe anticancerous compounds is a precious goal. The extraction of Corchorus olitorius mucilage (Jm) and its usage for selenium nanoparticles (SeNPs) biosynthesis was projected. The innovative formulation of bioactive nanocomposites (NCs) from Jm/SeNPs and chitosan nanoparticles (Cht) was also proposed to apply these NCs as effectual anticancers against CaCo-2 and HeLa cancerous cells. The Jm/SeNPs biosynthesis (mean diameter = 6.45 nm) was innovatively achieved and confirmed using infrared and ultraviolet-visible analysis. The constructions of different NCs were done (N1: 2Jm/SeNPs:1Cht; N2: 1Jm/SeNPs:1Cht; and N3: 1Jm/SeNPs:2Cht) with mean particles' diameter of 88.41, 46.86 and 69.35 nm, respectively. The cytotoxicity assay of constructed NCs indicated their potentialities to suppress examined cells; N1 (negatively charged; −16.2 mV) was the most forceful with IC50 of 12.36 and 73.15 mg/L against CaCo-2 and HeLa cells, respectively. The scanning microscopy imaging of treated CaCo-2 cells with N1 of Cht/Jm/SeNPs indicated that the NCs led to remarkable apoptotic destructions of treated cells, including cell shrinkage, membrane blebbing, cytoplasmic vacuolization, cell debris and apoptotic indices. The innovative NCs from Cht/Jm/SeNPs are promisingly recommended as effectual, natural and bioactive anticancer formulations against human cancers.
ISSN:0141-8130
1879-0003
1879-0003
DOI:10.1016/j.ijbiomac.2024.137320