Synergistic catecholamine and coordination chemistry for enhanced bioactivity and secondary grafting activity of zirconia dental implants

• Published in: Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2025-02, Vol.246, p.114361, Article 114361
• Main Authors: Gao, Peng, Zhang, Qihong, Sun, Yingyue, Cheng, Huan, Wu, Shuyi, Zhang, Yinyan, Si, Wen, Sun, Haobo, Sun, Ningyao, Yang, Jing, Cai, Kaiyong, Lu, Lei, Liu, Jinsong
• Format: Article
• Language: English
• Subjects: Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Bacteriostasis; Catecholamines - chemistry; Coated Materials, Biocompatible - chemistry; Coated Materials, Biocompatible - pharmacology; Dental Implants; Indoles - chemistry; Indoles - pharmacology; Mice; Osteogenesis; Osteogenesis - drug effects; Particle Size; Polyamines - chemistry; Polyamines - pharmacology; Polymers - chemistry; Polymers - pharmacology; Strontium - chemistry; Strontium - pharmacology; Surface modification; Surface Properties; Zirconia implant; Zirconium - chemistry
• ISSN: 0927-7765; 1873-4367; 1873-4367
• DOI: 10.1016/j.colsurfb.2024.114361

The inherent bioinertness of zirconia (ZrO2) hinders its early bone integration, presenting a significant obstacle to its widespread use in dental implant technologies. Addressing this, we developed a surface coating leveraging the synergistic effects of catecholamine and coordination chemistry inspired by the mussel byssus cuticle. This coating, named PDPA@Sr, is enriched with strontium ions and amine groups, resulting from a simple immersion of polydopamine (PD)-coated ZrO2 in an alkaline strontium chloride and poly(allylamine) (PA) solution. Compared to conventional mussel-inspired PD coatings, PDPA@Sr demonstrates enhanced aesthetic properties and mechanical stability. The continuous release of strontium ions from the coating significantly enhances osteogenesis, while the abundant surface amine groups offer notable antibacterial effects. More importantly, these amine groups also enable a variety of chemical modifications, including electrostatic adsorption, carbodiimide chemistry, Michael addition, Schiff base formation, and click chemistry, thus providing a multifaceted platform for the advanced surface modification of ZrO2 implants. •The PDPA@Sr coating promotes bone formation and inhibits bacterial growth.•The coating offers enhanced stability and allows for customizable hue adjustment.•The amino-rich coating provides a platform for customizable functionalities.