A Case of Anti-OJ Antibody-positive Antisynthetase Myopathy Diagnosed after Pulmonary Embolization

Idiopathic inflammatory myopathies, such as dermatomyositis, are implicated as possible risk factors for venous thromboembolism. We herein report the first known case of a 50-year-old woman who presented to our hospital with a fever, chest pain, and elevated creatine kinase levels and was ultimately...

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Bibliographic Details
Published in:Internal Medicine 2024, pp.4201-24
Main Authors: Nakanishi, Yu, Watanabe, Hirofumi, Tsuyuki, Yoshihiro, Tsuyuki, Mako, Kakumoto, Shinji, Abe, Masaaki, Hamai, Kosuke
Format: Article
Language:English
Subjects:
Anti-OJ antibody
Antisynthetase myopathy
Idiopathic inflammatory myopathy
Pulmonary embolism
Venous thromboembolism
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Summary:Idiopathic inflammatory myopathies, such as dermatomyositis, are implicated as possible risk factors for venous thromboembolism. We herein report the first known case of a 50-year-old woman who presented to our hospital with a fever, chest pain, and elevated creatine kinase levels and was ultimately diagnosed with pulmonary embolism and anti-OJ antibody-positive antisynthetase myopathy. Dermatomyositis may increase the risk of venous thromboembolism, including pulmonary embolism. However, only a few cases of pulmonary embolism developing before the diagnosis of inflammatory myositis have been reported. Idiopathic inflammatory myopathy should be considered as a differential diagnosis when creatine kinase levels are elevated in patients with pulmonary embolism.
ISSN:0918-2918
1349-7235
1349-7235
DOI:10.2169/internalmedicine.4201-24