Fecal Myeloperoxidase Levels Reflect Disease Activity in Children With Crohn's Disease

Crohn's disease (CD) is a major form of inflammatory bowel disease (IBD) which has relapsing and remitting symptoms. Better ways to detect and monitor active disease are required for early diagnosis and optimal outcomes. We assessed fecal myeloperoxidase (fMPO), a neutrophil-derived enzyme that...

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Bibliographic Details
Published in:Inflammatory bowel diseases 2024-11
Main Authors: Edwards, Teagan S, Ho, Shaun S C, Brown, Stephanie C, Appleton, Laura, Smith, Briana R, Borichevsky, Grace M, Swaminathan, Akhilesh, Frampton, Christopher M A, Gearry, Richard B, Kettle, Anthony J, Day, Andrew S
Format: Article
Language:English
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Summary:Crohn's disease (CD) is a major form of inflammatory bowel disease (IBD) which has relapsing and remitting symptoms. Better ways to detect and monitor active disease are required for early diagnosis and optimal outcomes. We assessed fecal myeloperoxidase (fMPO), a neutrophil-derived enzyme that produces hypochlorous acid, as a marker of disease activity in children with CD. This observational study assessed myeloperoxidase (MPO) levels in fecal samples from children aged
ISSN:1078-0998
1536-4844
1536-4844
DOI:10.1093/ibd/izae262