Visible Light-Induced Three-Component Alkoxyalkylation of Alkenes with α‑Halocarbonyls and Alcohols

A visible-light-induced three-component alkoxyalkylation of alkenes has been developed under the photocatalysis of fac-Ir­(ppy)3. The alkene substrate scope included aryl and aliphatic alkenes as well as electron-rich and electron-deficient alkenes, allowing the facile coupling with a diverse array...

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Bibliographic Details
Published in:Journal of organic chemistry 2024-12, Vol.89 (23), p.17621-17634
Main Authors: Chowdhury, Soumyadeep Roy, Kim, Hun Young, Oh, Kyungsoo
Format: Article
Language:English
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Summary:A visible-light-induced three-component alkoxyalkylation of alkenes has been developed under the photocatalysis of fac-Ir­(ppy)3. The alkene substrate scope included aryl and aliphatic alkenes as well as electron-rich and electron-deficient alkenes, allowing the facile coupling with a diverse array of α-halocarbonyl compounds. The redox potential-guided orchestration of radical processes with precision allows rapid access to highly functionalized products that are useful building blocks in organic synthesis.
ISSN:0022-3263
1520-6904
1520-6904
DOI:10.1021/acs.joc.4c02374