Epidemiology of Coloboma: Prevalence and Patterns in Texas, 1999–2014

ABSTRACTBackgroundColoboma is a rare congenital malformation in which part of the tissue that makes up the eye is missing and may cause visual impairment or blindness. Little is known about the epidemiology of this condition. Therefore, we obtained data from the Texas Birth Defects Registry on child...

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Bibliographic Details
Published in:Birth defects research 2024-11, Vol.116 (11), p.e2413-n/a
Main Authors: Mitchell, Danielle L., Chambers, Tiffany M., Agopian, A. J., Benjamin, Renata H., Shumate, Charles J., Slavotinek, Anne, Hufnagel, Robert B., Brooks, Brian P., Mitchell, Laura E., Lupo, Philip J.
Format: Article
Language:English
Subjects:
Adult
Birth defects
coloboma
Coloboma - epidemiology
congenital anomalies
Congenital defects
Demographic variables
Diabetes mellitus
Epidemiology
eye defects
Female
Humans
Infant
Infant, Newborn
Live Birth - epidemiology
Male
Prevalence
Registries
Regression analysis
Subgroups
Texas - epidemiology
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Summary:ABSTRACTBackgroundColoboma is a rare congenital malformation in which part of the tissue that makes up the eye is missing and may cause visual impairment or blindness. Little is known about the epidemiology of this condition. Therefore, we obtained data from the Texas Birth Defects Registry on children identified with coloboma for the period 1999–2014.MethodsUsing information on all live births from the same period, prevalence ratios (PRs) for selected demographic and clinical factors were used to estimate associations using Poisson regression among cases with coloboma. Coloboma cases were divided into subgroups to explore patterns of co‐occurring defects and syndromes. All variables significant in unadjusted models (p 
ISSN:2472-1727
2472-1727
DOI:10.1002/bdr2.2413