Anti-Inflammatory Secoiridoids from the Medicinal Herb Gentianopsis barbata

Five new secoiridoids, gentianopsins A-E (1-5), along with two known analogues (6 and 7) were isolated from the whole plants of the medicinal herb Gentianopsis barbata. Their structures were elucidated by a comparison of extensive spectroscopic analysis (1D and 2D NMR, and HRMS) and quantum chemical...

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Published in:Chemistry & biodiversity 2024-11, p.e202402653
Main Authors: Liu, Huan, Cheng, Hui-Zhen, Qi, Xiao-Yu, Fan, Yu-Zhou, Yuan, Zhong-Zhu, Xu, Yuan-Liang, Liu, Yan, Guo, Kai, Li, Sheng-Hong
Format: Article
Language:English
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Summary:Five new secoiridoids, gentianopsins A-E (1-5), along with two known analogues (6 and 7) were isolated from the whole plants of the medicinal herb Gentianopsis barbata. Their structures were elucidated by a comparison of extensive spectroscopic analysis (1D and 2D NMR, and HRMS) and quantum chemical calculations. Gentianopsins A (1) and B (2) represented two unusual skeletons of trihomo-secoiridoids. Anti-inflammatory activity of these isolates was evaluated via suppressing the secretion of cytokines TNF-α and IL-6 in LPS-induced macrophages RAW264.7. Significant inhibitory activity was observed for compounds 3 and 7 on IL-6 secretion with IC values of 10.22 and 13.30 μM, respectively.
ISSN:1612-1872
1612-1880
1612-1880
DOI:10.1002/cbdv.202402653