Diagnosis of TP53-mutated myeloid disease by the ICC and WHO 5th Edition Classifications

The International Consensus (ICC) and World Health Organization 5th edition (WHO5) classifications introduced new but differing categories of myeloid disease defined by TP53 mutations. We reviewed a cohort of 188 cases of TP53-mutated myeloid disease to determine how diagnoses and outcomes differ be...

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Bibliographic Details
Published in:Blood advances 2024-11
Main Authors: Hart, Stephanie A, Lee, Laura, Seegmiller, Adam, Mason, Emily Ferguson
Format: Article
Language:English
Online Access:Get full text
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Summary:The International Consensus (ICC) and World Health Organization 5th edition (WHO5) classifications introduced new but differing categories of myeloid disease defined by TP53 mutations. We reviewed a cohort of 188 cases of TP53-mutated myeloid disease to determine how diagnoses and outcomes differ between the two classifications. Overall, 120 (64%) cases were classified differently by the ICC and WHO5, including 24/80 (30%) cases with
ISSN:2473-9529
2473-9537
2473-9537
DOI:10.1182/bloodadvances.2024014140