Study on the Impact of Hormone Therapy for Prostate Cancer on the Quality of Life and the Psycho-Relational Sphere of Patients: ProQoL

Prostate cancer and its treatment, particularly androgen deprivation therapy (ADT), can profoundly impact patients' quality of life. The aim of the prospective observational study reported here was to evaluate the effects of ADT on various aspects of quality of life in men with prostate cancer...

Full description

Saved in:
Bibliographic Details
Published in:Oncology and therapy 2024-11
Main Authors: Cappuccio, Francesca, Buonerba, Carlo, Scafuri, Luca, Di Trolio, Rossella, Dolce, Pasquale, Trabucco, Serena Orsola, Erbetta, Filomena, Tulimieri, Elvira, Sciscio, Antonella, Ingenito, Concetta, Verde, Antonio, Di Lorenzo, Giuseppe
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c228t-9d30570878c1e9584e036aaff8a76fed704be397c78ae027bf07000f7c1b272b3
container_end_page
container_issue
container_start_page
container_title Oncology and therapy
container_volume
creator Cappuccio, Francesca
Buonerba, Carlo
Scafuri, Luca
Di Trolio, Rossella
Dolce, Pasquale
Trabucco, Serena Orsola
Erbetta, Filomena
Tulimieri, Elvira
Sciscio, Antonella
Ingenito, Concetta
Verde, Antonio
Di Lorenzo, Giuseppe
description Prostate cancer and its treatment, particularly androgen deprivation therapy (ADT), can profoundly impact patients' quality of life. The aim of the prospective observational study reported here was to evaluate the effects of ADT on various aspects of quality of life in men with prostate cancer at a community-based hospital in Southern Italy. Eligible men initiating hormonal therapy were recruited between December 2021 and December 2023. Data were collected at baseline (T ) and after 3 months (T ) and 6 months (T ) of ADT using standardized questionnaires (European Organization for Research and Treatment of Cancer [EORTC] QLQ-C30, EORTC QLQ-PR25) and semi-structured interviews. Of the 52 participants, 43 completed all three assessments. The EORTC QLQ-C30 showed a statistically significant worsening in physical functioning (mean score decrease from 83.8 at T to 76.7 at T ; p 
doi_str_mv 10.1007/s40487-024-00313-3
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3128817837</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3128817837</sourcerecordid><originalsourceid>FETCH-LOGICAL-c228t-9d30570878c1e9584e036aaff8a76fed704be397c78ae027bf07000f7c1b272b3</originalsourceid><addsrcrecordid>eNo9kc1u2zAQhImiQR04eYEeCh57UbskJZHqrTCa2oCBOD89ExS1hFVIokpSB71Anrty7OS0i8XMALMfIZ8ZfGMA8nvMIVcyA55nAIKJTHwg11yUZcZAVR_fdwkrchvjXwBgpZAs55_ISlSFKCQvrsnLU5qamfqBpiPSXT8am6h3dOtD7wekz0cMZpyp84Eego_JJKQbM1gMb6aHyXRtmk-ufeuQmqF5vR_ibI8-e8TOpNYPpqNP45KGJ-FhOeGQ4o9T6IPf35ArZ7qIt5e5Jn_ufj1vttn-_vdu83OfWc5VyqpGQCFBSWUZVoXKEURpjHPKyNJhIyGvUVTSSmUQuKzd0h_ASctqLnkt1uTrOXcM_t-EMem-jRa7zgzop6gF40oxqYRcpPwstUvtGNDpMbS9CbNmoE8I9BmBXhDoVwRaLKYvl_yp7rF5t7w9XPwHgHyBXw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3128817837</pqid></control><display><type>article</type><title>Study on the Impact of Hormone Therapy for Prostate Cancer on the Quality of Life and the Psycho-Relational Sphere of Patients: ProQoL</title><source>PubMed (Medline)</source><source>Springer Nature - SpringerLink Journals - Fully Open Access </source><source>Alma/SFX Local Collection</source><creator>Cappuccio, Francesca ; Buonerba, Carlo ; Scafuri, Luca ; Di Trolio, Rossella ; Dolce, Pasquale ; Trabucco, Serena Orsola ; Erbetta, Filomena ; Tulimieri, Elvira ; Sciscio, Antonella ; Ingenito, Concetta ; Verde, Antonio ; Di Lorenzo, Giuseppe</creator><creatorcontrib>Cappuccio, Francesca ; Buonerba, Carlo ; Scafuri, Luca ; Di Trolio, Rossella ; Dolce, Pasquale ; Trabucco, Serena Orsola ; Erbetta, Filomena ; Tulimieri, Elvira ; Sciscio, Antonella ; Ingenito, Concetta ; Verde, Antonio ; Di Lorenzo, Giuseppe</creatorcontrib><description>Prostate cancer and its treatment, particularly androgen deprivation therapy (ADT), can profoundly impact patients' quality of life. The aim of the prospective observational study reported here was to evaluate the effects of ADT on various aspects of quality of life in men with prostate cancer at a community-based hospital in Southern Italy. Eligible men initiating hormonal therapy were recruited between December 2021 and December 2023. Data were collected at baseline (T ) and after 3 months (T ) and 6 months (T ) of ADT using standardized questionnaires (European Organization for Research and Treatment of Cancer [EORTC] QLQ-C30, EORTC QLQ-PR25) and semi-structured interviews. Of the 52 participants, 43 completed all three assessments. The EORTC QLQ-C30 showed a statistically significant worsening in physical functioning (mean score decrease from 83.8 at T to 76.7 at T ; p &lt; 0.001), increased fatigue (from 23.7 to 35.2; p &lt; 0.001), and insomnia (from 23.7 to 31.8; p = 0.048) following ADT initiation. The QLQ-PR25 revealed a significant decline in sexual functioning (from 59 to 26.9; p &lt; 0.001) and sexual activity (from 27.3 to 12; p = 0.001). Interviews revealed a significant rise in the number of patients reporting depressed mood. Interviews also highlighted a worsening in body image perception and sexuality, increased feelings of dependence, and challenges in the social and relational spheres. ADT significantly impacts various aspects of quality of life in men with prostate cancer, particularly physical functioning, fatigue, sexual function, body image, and emotional well-being. These results underscore the critical importance of a comprehensive, patient-centered approach that addresses both the physical and psychosocial aspects of care.</description><identifier>ISSN: 2366-1070</identifier><identifier>ISSN: 2366-1089</identifier><identifier>EISSN: 2366-1089</identifier><identifier>DOI: 10.1007/s40487-024-00313-3</identifier><identifier>PMID: 39535725</identifier><language>eng</language><publisher>New Zealand</publisher><ispartof>Oncology and therapy, 2024-11</ispartof><rights>2024. The Author(s).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c228t-9d30570878c1e9584e036aaff8a76fed704be397c78ae027bf07000f7c1b272b3</cites><orcidid>0000-0002-7410-8300</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39535725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cappuccio, Francesca</creatorcontrib><creatorcontrib>Buonerba, Carlo</creatorcontrib><creatorcontrib>Scafuri, Luca</creatorcontrib><creatorcontrib>Di Trolio, Rossella</creatorcontrib><creatorcontrib>Dolce, Pasquale</creatorcontrib><creatorcontrib>Trabucco, Serena Orsola</creatorcontrib><creatorcontrib>Erbetta, Filomena</creatorcontrib><creatorcontrib>Tulimieri, Elvira</creatorcontrib><creatorcontrib>Sciscio, Antonella</creatorcontrib><creatorcontrib>Ingenito, Concetta</creatorcontrib><creatorcontrib>Verde, Antonio</creatorcontrib><creatorcontrib>Di Lorenzo, Giuseppe</creatorcontrib><title>Study on the Impact of Hormone Therapy for Prostate Cancer on the Quality of Life and the Psycho-Relational Sphere of Patients: ProQoL</title><title>Oncology and therapy</title><addtitle>Oncol Ther</addtitle><description>Prostate cancer and its treatment, particularly androgen deprivation therapy (ADT), can profoundly impact patients' quality of life. The aim of the prospective observational study reported here was to evaluate the effects of ADT on various aspects of quality of life in men with prostate cancer at a community-based hospital in Southern Italy. Eligible men initiating hormonal therapy were recruited between December 2021 and December 2023. Data were collected at baseline (T ) and after 3 months (T ) and 6 months (T ) of ADT using standardized questionnaires (European Organization for Research and Treatment of Cancer [EORTC] QLQ-C30, EORTC QLQ-PR25) and semi-structured interviews. Of the 52 participants, 43 completed all three assessments. The EORTC QLQ-C30 showed a statistically significant worsening in physical functioning (mean score decrease from 83.8 at T to 76.7 at T ; p &lt; 0.001), increased fatigue (from 23.7 to 35.2; p &lt; 0.001), and insomnia (from 23.7 to 31.8; p = 0.048) following ADT initiation. The QLQ-PR25 revealed a significant decline in sexual functioning (from 59 to 26.9; p &lt; 0.001) and sexual activity (from 27.3 to 12; p = 0.001). Interviews revealed a significant rise in the number of patients reporting depressed mood. Interviews also highlighted a worsening in body image perception and sexuality, increased feelings of dependence, and challenges in the social and relational spheres. ADT significantly impacts various aspects of quality of life in men with prostate cancer, particularly physical functioning, fatigue, sexual function, body image, and emotional well-being. These results underscore the critical importance of a comprehensive, patient-centered approach that addresses both the physical and psychosocial aspects of care.</description><issn>2366-1070</issn><issn>2366-1089</issn><issn>2366-1089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo9kc1u2zAQhImiQR04eYEeCh57UbskJZHqrTCa2oCBOD89ExS1hFVIokpSB71Anrty7OS0i8XMALMfIZ8ZfGMA8nvMIVcyA55nAIKJTHwg11yUZcZAVR_fdwkrchvjXwBgpZAs55_ISlSFKCQvrsnLU5qamfqBpiPSXT8am6h3dOtD7wekz0cMZpyp84Eego_JJKQbM1gMb6aHyXRtmk-ufeuQmqF5vR_ibI8-e8TOpNYPpqNP45KGJ-FhOeGQ4o9T6IPf35ArZ7qIt5e5Jn_ufj1vttn-_vdu83OfWc5VyqpGQCFBSWUZVoXKEURpjHPKyNJhIyGvUVTSSmUQuKzd0h_ASctqLnkt1uTrOXcM_t-EMem-jRa7zgzop6gF40oxqYRcpPwstUvtGNDpMbS9CbNmoE8I9BmBXhDoVwRaLKYvl_yp7rF5t7w9XPwHgHyBXw</recordid><startdate>20241113</startdate><enddate>20241113</enddate><creator>Cappuccio, Francesca</creator><creator>Buonerba, Carlo</creator><creator>Scafuri, Luca</creator><creator>Di Trolio, Rossella</creator><creator>Dolce, Pasquale</creator><creator>Trabucco, Serena Orsola</creator><creator>Erbetta, Filomena</creator><creator>Tulimieri, Elvira</creator><creator>Sciscio, Antonella</creator><creator>Ingenito, Concetta</creator><creator>Verde, Antonio</creator><creator>Di Lorenzo, Giuseppe</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7410-8300</orcidid></search><sort><creationdate>20241113</creationdate><title>Study on the Impact of Hormone Therapy for Prostate Cancer on the Quality of Life and the Psycho-Relational Sphere of Patients: ProQoL</title><author>Cappuccio, Francesca ; Buonerba, Carlo ; Scafuri, Luca ; Di Trolio, Rossella ; Dolce, Pasquale ; Trabucco, Serena Orsola ; Erbetta, Filomena ; Tulimieri, Elvira ; Sciscio, Antonella ; Ingenito, Concetta ; Verde, Antonio ; Di Lorenzo, Giuseppe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c228t-9d30570878c1e9584e036aaff8a76fed704be397c78ae027bf07000f7c1b272b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cappuccio, Francesca</creatorcontrib><creatorcontrib>Buonerba, Carlo</creatorcontrib><creatorcontrib>Scafuri, Luca</creatorcontrib><creatorcontrib>Di Trolio, Rossella</creatorcontrib><creatorcontrib>Dolce, Pasquale</creatorcontrib><creatorcontrib>Trabucco, Serena Orsola</creatorcontrib><creatorcontrib>Erbetta, Filomena</creatorcontrib><creatorcontrib>Tulimieri, Elvira</creatorcontrib><creatorcontrib>Sciscio, Antonella</creatorcontrib><creatorcontrib>Ingenito, Concetta</creatorcontrib><creatorcontrib>Verde, Antonio</creatorcontrib><creatorcontrib>Di Lorenzo, Giuseppe</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oncology and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cappuccio, Francesca</au><au>Buonerba, Carlo</au><au>Scafuri, Luca</au><au>Di Trolio, Rossella</au><au>Dolce, Pasquale</au><au>Trabucco, Serena Orsola</au><au>Erbetta, Filomena</au><au>Tulimieri, Elvira</au><au>Sciscio, Antonella</au><au>Ingenito, Concetta</au><au>Verde, Antonio</au><au>Di Lorenzo, Giuseppe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study on the Impact of Hormone Therapy for Prostate Cancer on the Quality of Life and the Psycho-Relational Sphere of Patients: ProQoL</atitle><jtitle>Oncology and therapy</jtitle><addtitle>Oncol Ther</addtitle><date>2024-11-13</date><risdate>2024</risdate><issn>2366-1070</issn><issn>2366-1089</issn><eissn>2366-1089</eissn><abstract>Prostate cancer and its treatment, particularly androgen deprivation therapy (ADT), can profoundly impact patients' quality of life. The aim of the prospective observational study reported here was to evaluate the effects of ADT on various aspects of quality of life in men with prostate cancer at a community-based hospital in Southern Italy. Eligible men initiating hormonal therapy were recruited between December 2021 and December 2023. Data were collected at baseline (T ) and after 3 months (T ) and 6 months (T ) of ADT using standardized questionnaires (European Organization for Research and Treatment of Cancer [EORTC] QLQ-C30, EORTC QLQ-PR25) and semi-structured interviews. Of the 52 participants, 43 completed all three assessments. The EORTC QLQ-C30 showed a statistically significant worsening in physical functioning (mean score decrease from 83.8 at T to 76.7 at T ; p &lt; 0.001), increased fatigue (from 23.7 to 35.2; p &lt; 0.001), and insomnia (from 23.7 to 31.8; p = 0.048) following ADT initiation. The QLQ-PR25 revealed a significant decline in sexual functioning (from 59 to 26.9; p &lt; 0.001) and sexual activity (from 27.3 to 12; p = 0.001). Interviews revealed a significant rise in the number of patients reporting depressed mood. Interviews also highlighted a worsening in body image perception and sexuality, increased feelings of dependence, and challenges in the social and relational spheres. ADT significantly impacts various aspects of quality of life in men with prostate cancer, particularly physical functioning, fatigue, sexual function, body image, and emotional well-being. These results underscore the critical importance of a comprehensive, patient-centered approach that addresses both the physical and psychosocial aspects of care.</abstract><cop>New Zealand</cop><pmid>39535725</pmid><doi>10.1007/s40487-024-00313-3</doi><orcidid>https://orcid.org/0000-0002-7410-8300</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2366-1070
ispartof Oncology and therapy, 2024-11
issn 2366-1070
2366-1089
2366-1089
language eng
recordid cdi_proquest_miscellaneous_3128817837
source PubMed (Medline); Springer Nature - SpringerLink Journals - Fully Open Access ; Alma/SFX Local Collection
title Study on the Impact of Hormone Therapy for Prostate Cancer on the Quality of Life and the Psycho-Relational Sphere of Patients: ProQoL
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T02%3A56%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Study%20on%20the%20Impact%20of%20Hormone%20Therapy%20for%20Prostate%20Cancer%20on%20the%20Quality%20of%20Life%20and%20the%20Psycho-Relational%20Sphere%20of%20Patients:%20ProQoL&rft.jtitle=Oncology%20and%20therapy&rft.au=Cappuccio,%20Francesca&rft.date=2024-11-13&rft.issn=2366-1070&rft.eissn=2366-1089&rft_id=info:doi/10.1007/s40487-024-00313-3&rft_dat=%3Cproquest_cross%3E3128817837%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c228t-9d30570878c1e9584e036aaff8a76fed704be397c78ae027bf07000f7c1b272b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3128817837&rft_id=info:pmid/39535725&rfr_iscdi=true