Association between the rs1800624 and rs80096349 SNPs and diabetic retinopathy: a pilot study

• Published in: Ophthalmic genetics 2024-11, p.1-7
• Main Authors: Alnaji, Haider Ali, Hasan, Aizhar H, Omran, Rabab, Al Nuwaini, Mohammed Qasim
• Format: Article
• Language: English
• ISSN: 1381-6810; 1744-5094; 1744-5094
• DOI: 10.1080/13816810.2024.2428783

One of the conditions that might harm your eyesight is diabetic retinopathy (DR), DR may set in slowly but surely for those with long-term diabetes and poor glucose control. ‎. To establish a connection between the various genotypes of the rs1800624 SNP and the rs80096349 SNP located in the gene and DR patients. ‎. The current case-control research examined one hundred thirty-four individuals diagnosed with type 2 diabetes and thirty-six healthy individuals who did not have DM. These samples were obtained from Amir Al-Muminin, a private hospital in Najaf, Iraq. The tetra primers ARMS-PCR method was utilized to determine the genotype of rs1800624 SNP of the gene. A significant association was found between genotypes (AA, AG, and GG) and DR subgroups (NPDR & PDR) in patients (  = 0.001). The AG genotype of rs1800624 SNP is associated with a lowering the risk of developing NPDR (OR = 0.30; 95% CI = 0.12-0.74;  = 0.009 between controls and NPDR, OR = 0.36; 95% CI = 0.14-0.90;  = 0.029 between NDR and NPDR). HRM analysis verified the presence of only two genotypes in the samples: wild type (GG) and a heterozygous mutant (GA). However, a significant association between genotypes was observed when comparing DR status with controls and NDR (  = 0.031). The rs1800624 SNP of the gene is associated with the risk of NPDR and PDR in T2DM, and the polymorphism of the rs80096349 may be associated with retinopathy in the Iraqi population.