Magnetoresponsive liposomes applications in nanomedicine: A comprehensive review

• Published in: Biomedicine & pharmacotherapy 2024-12, Vol.181, p.117665, Article 117665
• Main Authors: Shahsavari, Shayan, Rad, Mohammad Behnam, Hajiaghajani, Amirhossein, Rostami, Mohammadreza, Hakimian, Fatemeh, Jafarzadeh, Sina, Hasany, Masoud, Collingwood, Joanna F., Aliakbari, Farhang, Fouladiha, Hamideh, Bardania, Hassan, Otzen, Daniel E., Morshedi, Dina
• Format: Article
• Language: English
• Subjects: Lipid; Magnetic nanoparticles; Magnetoresponsive; Metal chelates; MRI; Theranostics
• ISSN: 0753-3322; 1950-6007; 1950-6007
• DOI: 10.1016/j.biopha.2024.117665

Safe and effective cancer therapy requires a suitable nanocarrier that can target particular sites, such as cancer cells, in a selective manner. With the tremendous growth in nanotechnology, liposomes, among various competing nanocarriers, have shown promising advances in cancer therapy. Magnetic nanoparticles and metal ions are wide-reaching candidates for conferring magnetic properties and for incorporation into liposomes. Combining liposomes with magnetic structures enables construction of magnetoresponsive liposomes, allowing stimuli-responsiveness to an alternating magnetic field, magnetic targeting, and tracking by magnetic resonance imaging, which could all occur in parallel. This review presents a comprehensive analysis of the practical advances and novel aspects of design, synthesis and engineering magnetoresponsive liposomes, emphasizing their diverse properties for various applications. Our work explores the innovative uses of these structures, extending beyond drug delivery to include smart contrast agents, cell labeling, biosensing, separation, and filtering. By comparing new findings with earlier studies, we showcase significant improvements in efficiency and uncover new potentials, setting a new benchmark for future research in the field of magnetoresponsive liposomes. [Display omitted] •Integrating chelated metals and magnetic nanoparticles with liposomes to create magnetoliposomes (MLs).•Structure and properties of multi-lobed magnetic liposomes (MMLs) were discussed.•Benefits of hyperthermia therapy and magnetic resonance imaging (MRI) using MLs were explored.•Potential of MLs for drug delivery and theranostics was examined.•The role of MLs in enhancing sensor precision and accuracy was analyzed.