Association of BRAF V600E allele frequency with clinicopathologic outcomes in papillary thyroid cancer

BRAF V600E mutation is the most common genetic driver of papillary thyroid cancer (PTC), where it is found with various allele frequency (AF), reflecting the proportion of cells carrying the mutant and wild-type gene alleles. To determine whether BRAF V600E AF can improve prognostication and inform...

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Published in:The journal of clinical endocrinology and metabolism 2024-11
Main Authors: Schumm, Max A, Nikiforov, Yuri E, Nikiforova, Marina N, Wald, Abigail I, Tseng, Chi-Hong, Smooke-Praw, Stephanie, Wu, James X, Yeh, Michael W, Livhits, Masha J
Format: Article
Language:English
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Summary:BRAF V600E mutation is the most common genetic driver of papillary thyroid cancer (PTC), where it is found with various allele frequency (AF), reflecting the proportion of cells carrying the mutant and wild-type gene alleles. To determine whether BRAF V600E AF can improve prognostication and inform initial surgical management of PTC. Retrospective cohort study (2016-2019). UCLA health. Consecutive patients with Bethesda V/VI nodules and isolated BRAF V600E mutation who underwent surgery with histopathology showing PTC. Blinded ThyroSeq v3 molecular analysis after completion of initial management and follow-up. Aggressive histopathology and cancer persistence/recurrence. Of 73 patients, the median BRAF V600E AF was 25.5% (IQR, 16.7-34.3%). Higher median AF was seen in patients classified as American Thyroid Association (ATA) high-risk (37%) vs. intermediate-risk (25.3%, p
ISSN:0021-972X
1945-7197
1945-7197
DOI:10.1210/clinem/dgae774