Laparoscopic fundoplication improves esophageal motility in patients with gastroesophageal reflux disease: a high-volume single-center controlled study in the era of high-resolution manometry and 24-hour pH impedance

• Published in: Journal of gastrointestinal surgery 2025-02, Vol.29 (2), p.101888, Article 101888
• Main Authors: Vittori, Arianna, Capovilla, Giovanni, Salvador, Renato, Santangelo, Matteo, Provenzano, Luca, Nicoletti, Loredana, Costantini, Andrea, Forattini, Francesca, Pittacolo, Matteo, Moletta, Lucia, Savarino, Edoardo V., Valmasoni, Michele
• Format: Article
• Language: English
• Subjects: 24-hour pH impedance; Adult; Aged; Electric Impedance; Esophageal motility; Esophageal pH Monitoring; Esophagus - physiopathology; Esophagus - surgery; Female; Fundoplication; Fundoplication - methods; Gastroesophageal Reflux - physiopathology; Gastroesophageal Reflux - surgery; Gastroesophageal reflux disease; High-resolution manometry; Humans; Laparoscopy - methods; Male; Manometry - methods; Middle Aged; Prospective Studies; Treatment Outcome
• ISSN: 1091-255X; 1873-4626; 1873-4626
• DOI: 10.1016/j.gassur.2024.101888

Most existing literature studies reported that laparoscopic fundoplication (LF) is safe in the setting of ineffective or weak peristalsis. However, the effect of the wrap on esophageal motility is still debated. This study aimed to assess how a functioning and effective fundoplication could affect esophageal motility in patients with gastroesophageal reflux disease (GERD). This study analyzed prospectively collected data on patients who underwent laparoscopic Nissen (LN) fundoplication or laparoscopic Toupet (LT) fundoplication for GERD at our department between 2010 and 2022. Demographic and clinical characteristics were recorded. Patients were evaluated using the Gastroesophageal Reflux Disease Questionnaire (GerdQ), barium swallow, endoscopy, high-resolution manometry (HRM), and 24-hour pH impedance (multichannel intraluminal impedance and pH monitoring [MII-pH]) before and after surgery. HRM was reviewed by 2 experts, following the criteria of the Chicago Classification (version 4.0). LF failure was objectively defined in case of abnormal postoperative MII-pH according to the Lyon 2.0 criteria with/without an abnormal GerdQ. During the study period, 124 patients with GERD (89 males and 35 females) were recruited. Of note, 58 patients underwent LN fundoplication, and 66 patients underwent LT fundoplication. All procedures were completed laparoscopically, and the 90-day postoperative mortality was nil. At the postoperative MII-pH, good outcome was recorded in 103 patients, and failure was recorded in 21 patients. There was a significant association between a successful LF and the normalization of esophageal motility (P