Prevalence of cardiometabolic outcomes in women who underwent salpingo-oophorectomy to prevent hereditary breast and ovarian cancer: a meta-analysis

• Published in: Familial cancer 2025-03, Vol.24 (1), p.5, Article 5
• Main Authors: Moraes, Francisco Cezar Aquino de, Moro, Lucca Dal, Souza, Maria Eduarda Cavalcanti, Rodrigues, Anna Luíza Soares de Oliveira, Sano, Vitor Kendi Tsuchiya, Barbosa, Bárbara Ferraz, Pacheco, Lucas Gama, Cunha, Daniel Ferreira, Queiroz, Otávio Luiz de, Souza, Dilma do Socorro Moraes de, Feio, Danielle, Stecca, Carlos, Burbano, Rommel Mario Rodríguez
• Format: Article
• Language: English
• Subjects: Biomedical and Life Sciences; Biomedicine; Body mass index; BRCA1 protein; BRCA1 Protein - genetics; BRCA2 protein; BRCA2 Protein - genetics; Breast; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - surgery; Cancer Research; Cardiovascular diseases; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; Cardiovascular Diseases - prevention & control; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - genetics; Epidemiology; Female; Heart attacks; Hereditary Breast and Ovarian Cancer Syndrome - epidemiology; Hereditary Breast and Ovarian Cancer Syndrome - genetics; Human Genetics; Humans; Hypercholesterolemia; Hypercholesterolemia - epidemiology; Hypercholesterolemia - genetics; Hypertension; Hypertension - epidemiology; Menopause; Meta-analysis; Metabolic disorders; Metabolism; Myocardial infarction; Myocardial Infarction - epidemiology; Oophorectomy; Original Article; Ovarian cancer; Ovarian Neoplasms - epidemiology; Ovarian Neoplasms - genetics; Ovarian Neoplasms - prevention & control; Ovarian Neoplasms - surgery; Ovariectomy; Point mutation; Prevalence; Salpingo-oophorectomy - statistics & numerical data; Statistical analysis; Womens health
• ISSN: 1389-9600; 1573-7292; 1573-7292
• DOI: 10.1007/s10689-024-00431-x

Risk reduction salpingo-oophorectomy (RRSO) is usually performed in women with hereditary breast and ovarian cancer (HBOC) syndrome for BRCA1 and BRCA2 gene mutation carriers, resulting in surgical menopause, which is more associated with a high risk of cardiovascular and metabolic disease than in premenopausal and natural menopausal women. This study assessed the prevalence of cardiovascular and metabolic outcomes in women who underwent salpingo-oophorectomy as a preventive measure against HBOC. This meta-analysis assessed prevalence rates for four metabolic/cardiovascular conditions: myocardial infarction, hypertension, hypercholesterolemia, and type 2 diabetes mellitus. DerSimonian and Laird random-effects models were applied to all analyses, with 95% confidence interval (CI). Heterogeneity was assessed with I². We used OpenMeta Analyst software for statistical analysis. A total of five retrospective studies and one observational study involving 1,320 patients were included. The average body mass index (BMI) was 25.97 kg/m2 and the average waist circumference was 87.94 cm. The analysis across a mean 4.94-year follow-up revealed prevalence rates for acute myocardial infarction of 1.5% (95% CI 0.3–2.7; P  = 0.077; I²=56.25%), hypertension of 28% (95% CI 6.9–49.1; P