Localised multiple spiradenomas are caused by somatic mosaicism in ALPK1 hotspot mutation

Spiradenocarcinomas, a rare skin adnexal tumour, are linked to the ALPK1 hotspot mutation. This study reveals that spiradenocarcinoma, accompanied by multiple localized spiradenomas, is caused by somatic mosaicism in the ALPK1 mutation hotspot.

Saved in:
Bibliographic Details
Published in:British journal of dermatology (1951) 2024-11
Main Authors: Hirano-Lotman, Yui, Ishida, Yoshihiro, Doi, Hiromi, Ogawa, Seishi, Kabashima, Kenji
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Spiradenocarcinomas, a rare skin adnexal tumour, are linked to the ALPK1 hotspot mutation. This study reveals that spiradenocarcinoma, accompanied by multiple localized spiradenomas, is caused by somatic mosaicism in the ALPK1 mutation hotspot.
ISSN:0007-0963
1365-2133
1365-2133
DOI:10.1093/bjd/ljae448