Lewis Acid Promotes Three-Component Cyclization to Construct Dithioxazole Derivatives

A simple and effective strategy for the construction of disulfide-substituted oxazole derivatives from amides, ynals, and acetyl disulfides via a Lewis acid-promoted three-component reaction has been reported. In addition, this reaction possesses other unique advantages, such as transition-metal-fre...

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Bibliographic Details
Published in:Journal of organic chemistry 2024-12, Vol.89 (23), p.17228-17236
Main Authors: Zou, Kai, Li, Anquan, Chen, Yitong, Cao, Gao, Zhu, Baofu
Format: Article
Language:English
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Summary:A simple and effective strategy for the construction of disulfide-substituted oxazole derivatives from amides, ynals, and acetyl disulfides via a Lewis acid-promoted three-component reaction has been reported. In addition, this reaction possesses other unique advantages, such as transition-metal-free catalysis, the production of disulfides, good functional group tolerance, and good regioselectivity.
ISSN:0022-3263
1520-6904
1520-6904
DOI:10.1021/acs.joc.4c01723