Slowing myopia progression with cylindrical annular refractive elements (CARE) spectacle lenses-Year 1 results from a 2-year prospective, multi-centre trial

• Published in: Acta ophthalmologica (Oxford, England) England), 2024-11
• Main Authors: Chen, Xiaoqin, Wu, Min, Yu, Cui, Ohlendorf, Arne, Rifai, Katharina, Boeck-Maier, Christina, Wahl, Siegfried, Yang, Youhua, Zhu, Yi, Li, Lihua, Sankaridurg, Padmaja
• Format: Article
• Language: English
• ISSN: 1755-375X; 1755-3768; 1755-3768
• DOI: 10.1111/aos.16795

To evaluate the effectiveness of 12 months of spectacle lens wear incorporating cylindrical annular refractive elements (CARE) in slowing myopia progression compared to single vision (SV) spectacle wear. In an ongoing 2-year prospective, double-masked, multi-centre clinical trial, 240 Chinese children aged 6-13 years, spherical equivalent refractive error (SE) -0.75 D to -5.00 D were randomised to one of three groups of 80 participants each to wear: SV spectacle lens (N = 80), CARE spectacles (7 mm central clear zone surrounded by treatment zone incorporating CARE with mean surface power of +4.6 D) and CARE S (9 mm central clear zone surrounded by treatment zone comprising CARE with mean surface power of +3.8 D). Cycloplegic SE and axial length (AL) were measured at 6-month intervals. Compared to baseline, changes in SE and AL were significantly different between the groups at both 6 and 12 months (p