Recent developments in the biomedical and anticancer applications of chitosan derivatives

• Published in: International journal of biological macromolecules 2024-12, Vol.283 (Pt 2), p.137601, Article 137601
• Main Authors: Rafiq, Muqadas, Ahmed, Jalal, Alturaifi, Huriyyah A., Awwad, Nasser S., Ibrahium, Hala A., Mir, Sadullah, Maalik, Aneela, Sabahat, Sana, Hassan, Safia, Khan, Zia Ul Haq
• Format: Article
• Language: English
• Subjects: Animals; Anti-cancer; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Biocompatible Materials - chemistry; Biocompatible Materials - pharmacology; Biomedical; Chitosan; Chitosan - analogs & derivatives; Chitosan - chemistry; Chitosan - pharmacology; Drug delivery; Humans; Neoplasms - drug therapy; Tissue Engineering
• ISSN: 0141-8130; 1879-0003; 1879-0003
• DOI: 10.1016/j.ijbiomac.2024.137601

Chitosan is a natural polymer derived from chitin. It has significant applications in various fields due to its unique physicochemical properties, biocompatibility, and biodegradability. These important properties of chitosan make it an attractive candidate for various anti-cancer activities and biomedical applications, including tissue engineering. This review emphasizes the latest literature on anticancer applications of chitosan derivatives and in-depth study of biomedical applications. This review highlights the importance of biomedical applications and anti-cancer activities like breast, liver, colon, gastric, melanoma, colorectal, cervical, oral, and lymphoma cancer. Currently, there is a notable absence of recent reviews that comprehensively address these aspects such as Alejandro Elizalde-Cárdenas, et al. 2024, focuses only on Biomedical applications of Cs and its derivatives (Elizalde-Cárdenas et al., 2024). Jingxian Ding, et al. 2022 discussed the applications of Cs in some Cancer treatments (Mabrouk et al., 2024). However, our article aims to provide a comprehensive overview of the latest advancements in Cs derivatives in both fields. This manuscript is designed with proper diagrams, flow sheets and summarized tables to enhance the understanding of the reader. It also highlights recent advancements in the development of various chitosan derivatives, offering a comprehensive perspective for researchers and practitioners to further progress in biomedical and anticancer technologies. [Display omitted] •Modification of Chitosan from various methods•Antibacterial activities of the derivatives of chitosan•Anticancer activities of the derivatives of chitosan•Antioxidant activities of the derivatives of chitosan•Biomedical activities of the derivatives of chitosan