Eradication of Candida auris biofilm in vitro by a polygalacturonic and caprylic acid wound ointment

Candida auris is a rapidly spreading virulent pathogen frequently resistant to multiple antifungal drugs that can form biofilms and infect wounds. Hence, there is a need for C. auris wound treatments not posing risks for developing antifungal resistance. We tested the ability of a polygalacturonic a...

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Published in:Journal de mycologie médicale 2024-12, Vol.34 (4), p.101519, Article 101519
Main Authors: Truong, Y-Lan, Rosenblatt, Joel, Gerges, Bahgat, Jiang, Ying, Raad, Issam
Format: Article
Language:English
Subjects:
Antifungal Agents - administration & dosage
Antifungal Agents - pharmacology
Biofilm eradication
Biofilms - drug effects
Candida auris
Candida auris - drug effects
Candidiasis - drug therapy
Candidiasis - microbiology
Caprylates - pharmacology
Caprylic acid
Honey
Humans
Microbial Sensitivity Tests
Ointments
Pectins - administration & dosage
Pectins - pharmacology
Polygalacturonic acid
Wound Infection - drug therapy
Wound Infection - microbiology
Wound Infection - prevention & control
Wound ointment
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Summary:Candida auris is a rapidly spreading virulent pathogen frequently resistant to multiple antifungal drugs that can form biofilms and infect wounds. Hence, there is a need for C. auris wound treatments not posing risks for developing antifungal resistance. We tested the ability of a polygalacturonic and caprylic acid ointment (PG+CAP) to rapidly eradicate C. auris biofilms within 2-hour exposures in an in vitro model. Medical-grade honey (MediHoney) wound ointment was used as a comparator. Nine different C. auris strains were tested. PG+CAP eradicated biofilms of 8 of the 9 tested strains and produced a > 5-log10 reduction of the ninth. MediHoney produced reductions ranging from 2 to 4 log10 without fully eradicating any strains. The differences between PG+CAP and MediHoney were statistically significant (p < 0.05). These results suggest that PG+CAP is a promising antimicrobial ointment warranting further in vivo study in wounds which may be colonized by C. auris biofilms.
ISSN:1156-5233
1773-0449
1773-0449
DOI:10.1016/j.mycmed.2024.101519