Linking CDH1 SNPs to gastric cancer risk: a comprehensive analysis of rs16260, rs13689, and rs9929218

Objective Single nucleotide polymorphisms (SNPs) are linked to carcinogenesis. Pathogenic variants in the CDH1 gene are associated with gastric cancer. This study examines the genotype and allele frequencies of three SNPs (rs16260, rs13689, and rs9929218) in the CDH1 gene and their relationship with...

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Bibliographic Details
Published in:Molecular biology reports 2024-12, Vol.51 (1), p.1162-1162, Article 1162
Main Authors: Aslan, Fırat, Almalı, Necat, Kaya, Zehra, Güven, Mustafa, Şahin, Elif Sena, Özdemir, Abdulselam, Duran, Seren, Binici, Serhat, Karan, Burak Muğdat, Uygur, Serhat
Format: Article
Language:English
Subjects:
Adult
Aged
Alleles
Animal Anatomy
Animal Biochemistry
Antigens, CD - genetics
Biomedical and Life Sciences
Cadherins - genetics
Carcinogenesis
Case-Control Studies
CDH1 gene
disease susceptibility
E-cadherin
Female
Gastric cancer
Gene frequency
Gene Frequency - genetics
Genetic Predisposition to Disease - genetics
Genotype
Genotype & phenotype
Histology
histopathology
Humans
Life Sciences
Male
Middle Aged
Morphology
Original Article
Polymorphism, Single Nucleotide - genetics
risk
Risk Factors
Single-nucleotide polymorphism
stomach neoplasms
Stomach Neoplasms - genetics
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Summary:Objective Single nucleotide polymorphisms (SNPs) are linked to carcinogenesis. Pathogenic variants in the CDH1 gene are associated with gastric cancer. This study examines the genotype and allele frequencies of three SNPs (rs16260, rs13689, and rs9929218) in the CDH1 gene and their relationship with gastric cancer risk. Materials and methods The study involved 105 gastric cancer patients with pathology results and 105 healthy controls. Clinical, histopathological, and demographic data were collected and compared between the two groups. Results No significant differences were found for rs16260 (− 160 C > A) and rs9929218 (G > A) between patients and controls (p > 0.05). For rs13689 (T > C), the T allele frequency was 90% in patients versus 69% in controls, while the C allele frequency was 10% in patients versus 31% in controls. A significant difference was observed for this SNP, with a higher T allele frequency in patients (OR = 4.03 CI95% 2.4–6.7, p 
ISSN:0301-4851
1573-4978
1573-4978
DOI:10.1007/s11033-024-10094-7