Intrinsic versus extrinsic contribution to intraindividual sweat rate variability of individual eccrine glands

The purpose of the current study was twofold. First, to determine the intraindividual variability of sweat rate per gland for a given skin location during exercise in the heat. Second, to determine the relative importance of intrinsic vs. extrinsic factors as the source of the intraindividual variab...

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Bibliographic Details
Published in:Autonomic neuroscience 2024-12, Vol.256, p.103218, Article 103218
Main Authors: Woolf, Emily K., Wells, Nicole, Moore, Jeff, Northway, Sarah, Buono, Michael J.
Format: Article
Language:English
Subjects:
Adult
Eccrine Glands - physiology
Eccrine sweat gland
Exercise
Exercise - physiology
Female
Forearm - physiology
Hot Temperature
Humans
Iontophoresis - methods
Male
Muscarinic Agonists - pharmacology
Pilocarpine - pharmacology
Sweat rate
Sweat rate variability
Sweating - physiology
Young Adult
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Summary:The purpose of the current study was twofold. First, to determine the intraindividual variability of sweat rate per gland for a given skin location during exercise in the heat. Second, to determine the relative importance of intrinsic vs. extrinsic factors as the source of the intraindividual variability in the sweat rate per gland. Sweat rate of individual eccrine glands on the forearm was measured following pilocarpine iontophoresis and during exercise in the heat. In five participants during exercise in the heat, the measured sweat rate for individual forearm eccrine glands (n = 500) ranged from 0.5 nL/gland/min to 16 nL/gland/min, or over a 30-fold difference. The mean (SD) intraindividual coefficient of variation in sweat rate per gland was 36 (5)% and 49 (10)% (p = 0.008) following pilocarpine iontophoresis and during exercise in the heat, respectively. Such results suggest that intrinsic factors (i.e., sweat gland size and cholinergic sensitivity) contribute approximately three times more than extrinsic factors (i.e., sweat gland nerve fiber density and threshold amplitude) towards explaining the large intra-person variability in sweat rate per gland seen during exercise in the heat. •Intraindividual variability in sweat rate of individual eccrine glands is unknown.•Locally induced sweating had a coefficient of variation of 36(5)%.•Sweating during heated exercise had a coefficient of variation of 49(10)%.•Intrinsic factors contribute ~3-fold more to variability than extrinsic factors.
ISSN:1566-0702
1872-7484
1872-7484
DOI:10.1016/j.autneu.2024.103218