Therapeutic potential of resveratrol and autologous chondrocytes in male rat knee joint cartilage repair

• Published in: Natural product research 2024-11, p.1-15
• Main Authors: Akhlagh, Alireza, Iraji, Aida, Daneshi, Seyyed Sajad, Kian, Mehdi, Jamshidzadeh, Akram, Zare, Shahrokh, Tanideh, Nader, Naseh, Maryam, Mussin, Nadiar M, Kurmanalina, Madina A, Tamadon, Amin
• Format: Article
• Language: English
• ISSN: 1478-6419; 1478-6427; 1478-6427
• DOI: 10.1080/14786419.2024.2429111

Osteochondral defects (OCDs) in synovial joints are caused by trauma or inflammatory joint diseases, with no definitive treatment available. This study examined the effects of resveratrol and chondrocyte injections in a rat model of OCD. Twenty-four male Sprague-Dawley rats were divided into four groups: a control group, a resveratrol-only group (10 mg/kg), a chondrocyte-only group (1 × 10 cells), and a combined treatment group that received both treatments. After two months, the rats were euthanized, and their knee joints were analysed histologically and immunohistochemically. The results showed that the combined resveratrol and chondrocyte treatment significantly reduced fibrous tissue, increased cartilage tissue volume, improved cellular distribution, and enhanced the regularity of the articular surface. Collagen types I and II and proteoglycan levels were also elevated. These findings suggest that the combination of resveratrol and chondrocytes has a synergistic effect, promoting effective OCD repair in this rat model, offering potential for future therapeutic approaches.