TFAA mediated one-pot synthesis of chiral N -protected amino acid-derived 1,2,4-oxadiazoles and their antibacterial studies

A scalable and environment-friendly one-pot two-component synthesis of chiral -protected amino acid substituted 1,2,4-oxadiazoles from hydroxyl amidine and ( )-2-(2,2,2-trifluoroacetamido)propanoic 2,2,2-trifluoroacetic anhydride is described. This operationally simple methodology affords an efficie...

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Published in:Organic & biomolecular chemistry 2024-11
Main Authors: Saravanakumar, Srinivasan Pon, Nagasundaram, Nagarajan, DhineshKumar, Jayaraman, Rajalakshmi, Periyaswamy, Lalitha, Appaswami
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container_title Organic & biomolecular chemistry
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creator Saravanakumar, Srinivasan Pon
Nagasundaram, Nagarajan
DhineshKumar, Jayaraman
Rajalakshmi, Periyaswamy
Lalitha, Appaswami
description A scalable and environment-friendly one-pot two-component synthesis of chiral -protected amino acid substituted 1,2,4-oxadiazoles from hydroxyl amidine and ( )-2-(2,2,2-trifluoroacetamido)propanoic 2,2,2-trifluoroacetic anhydride is described. This operationally simple methodology affords an efficient and convenient solution to synthesize chiral -protected amino acids under catalyst-free conditions. All the synthesized compounds were screened for their antibacterial activity towards six human pathogenic bacterial species, among which, 4al exhibited a significant efficacy against with the MIC value of 0.19 μg mL .
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title TFAA mediated one-pot synthesis of chiral N -protected amino acid-derived 1,2,4-oxadiazoles and their antibacterial studies
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