Clinical characteristics of pulmonary cryptococcosis patients with different immune statuses: A 10-year multicenter retrospective study in China

We aimed to evaluate clinical characteristics and therapeutic efficacy of pulmonary cryptococcosis (PC) in patients with different immune status in a large multicenter population to support appropriate clinical management of this public health threat. We retrospectively investigated the medical reco...

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Bibliographic Details
Published in:Respiratory medicine 2024-12, Vol.235, p.107866, Article 107866
Main Authors: Wang, Hansheng, Han, Wenya, Yang, Chengqing, Hu, Hongling, Zheng, Yulan, He, Li, Zhu, Miaojuan, Tu, Qiujie, Nan, Lulu, Hu, Fuying, Li, Wentian, Tang, Yijun, Wang, Meifang
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antifungal Agents - therapeutic use
China - epidemiology
Cryptococcosis - drug therapy
Cryptococcosis - epidemiology
Cryptococcosis - immunology
Cryptococcus capsular antigen (CrAg)
Culture
Female
Histopathology
Humans
Immunocompetence
Immunocompetent
Immunocompromised Host - immunology
Immunodeficiency
Immunologic Deficiency Syndromes - complications
Immunologic Deficiency Syndromes - immunology
Incidence
Lung Diseases, Fungal - diagnosis
Lung Diseases, Fungal - drug therapy
Lung Diseases, Fungal - epidemiology
Lung Diseases, Fungal - immunology
Male
Middle Aged
Pulmonary cryptococcosis
Retrospective Studies
Treatment Outcome
Young Adult
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Summary:We aimed to evaluate clinical characteristics and therapeutic efficacy of pulmonary cryptococcosis (PC) in patients with different immune status in a large multicenter population to support appropriate clinical management of this public health threat. We retrospectively investigated the medical records of 510 patients with PC from January 2014 to June 2023 in 10 representative regional tertiary teaching hospitals in Hubei province of China, and clinical data of these patients were then stratified by different immune statuses. Immunocompetent (IC) patients accounted for 68.8 % (351/510), mild-to-moderate immunodeficiency (MID) patients accounted for 16.7 % (85/510), and severe immunodeficiency (SID) patients accounted for 14.5 % (74/510). PC patients in the MID and SID groups had a higher incidence of central nervous system (CNS) involvement than that in the IC group [4.7 % (MID) vs. 8.1 % (SID) vs. 1.1 % (IC), p = 0.002]. Patients with fever in SID group (35.1 %, 26/74) was more common (p 
ISSN:0954-6111
1532-3064
1532-3064
DOI:10.1016/j.rmed.2024.107866