Chronic treatment with SGLT-2 inhibitors is associated with ICU admission and disease severity in patients with diabetic ketoacidosis: a propensity score-matched cohort study

SGLT-2 inhibitors (SGLT-2i) are linked to a higher risk of diabetic ketoacidosis (DKA). However, it is still unclear whether the severity of SGLT-2i associated DKA is higher. This is a retrospective cohort study with patients admitted for DKA at a tertiary hospital (2013-2024). Patients were matched...

Full description

Saved in:
Bibliographic Details
Published in:Internal and emergency medicine 2024-11
Main Authors: Sebastian-Valles, Fernando, Tapia-Sanchiz, Maria Sara, Navas-Moreno, Victor, Lopez-Ruano, Marta, Martínez-Otero, Carmen, Carrillo-López, Elena, Sager La Ganga, Carolina, Raposo-López, Juan José, Amar, Selma, González-Castañar, Sara, Von Wernitz Teleki, Andres, Del Arco, Carmen, Arranz-Martín, Jose Alfonso, Marazuela, Mónica
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:SGLT-2 inhibitors (SGLT-2i) are linked to a higher risk of diabetic ketoacidosis (DKA). However, it is still unclear whether the severity of SGLT-2i associated DKA is higher. This is a retrospective cohort study with patients admitted for DKA at a tertiary hospital (2013-2024). Patients were matched by propensity score for age, sex, diabetes duration, type, and ischemic heart disease. ICU admission risk and clinical severity were compared between SGLT-2i users and controls. The matched sample included 105 subjects (35 SGLT-2i users, 70 controls). The average age was 63.1 ± 15.4 years, and 40 (38.1%) patients were women. ICU admission was higher in the treatment group (65.7% versus 24.6%, p 
ISSN:1828-0447
1970-9366
1970-9366
DOI:10.1007/s11739-024-03813-2