The challenges of difficult-to-treat Acinetobacter infections

SUMMARYInfections due to spp. are among the most difficult to treat. Most are resistant to standard antibiotics, and there is difficulty in distinguishing colonizers from pathogens. This mini-review examines the available antibiotics that exhibit activity against these organisms and provides guidanc...

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Bibliographic Details
Published in:Clinical microbiology reviews 2024-12, Vol.37 (4), p.e0009324
Main Authors: Richards, Guy A, Perovic, Olga, Brink, Adrian J
Format: Article
Language:English
Subjects:
Acinetobacter - drug effects
Acinetobacter Infections - drug therapy
Acinetobacter Infections - microbiology
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antimicrobial Chemotherapy
Drug Resistance, Bacterial
Humans
Microbial Sensitivity Tests
Review
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Summary:SUMMARYInfections due to spp. are among the most difficult to treat. Most are resistant to standard antibiotics, and there is difficulty in distinguishing colonizers from pathogens. This mini-review examines the available antibiotics that exhibit activity against these organisms and provides guidance as to which cultures are relevant and how to treat active infections. Antibiograms describing resistance mechanisms and the minimum inhibitory concentration (MIC) are essential to determine which agent or combination of agents should be used after confirmation of infection, utilizing clinical parameters and biomarkers such as procalcitonin. Directed therapy should be prompt as despite its reputation as a colonizer, the attributable mortality is high. However, although combination therapy is advised, no specific combination has definite evidence of superiority.
ISSN:0893-8512
1098-6618
1098-6618
DOI:10.1128/cmr.00093-24