Cobalt-Catalyzed Regioselective C8–H Sulfoxamination of 1‑Naphthylamine Derivatives with NH-Sulfoximines

A simple cobalt-catalyzed, picolinamide-directed C8–H sulfoxamination of 1-naphthalamides with NH-sulfoximines has been developed. This cross-dehydrogenative C–H/N–H coupling reaction offers a facile route to N-arylated sulfoximines, exhibiting high yields, a broad substrate scope, and excellent fun...

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Bibliographic Details
Published in:Journal of organic chemistry 2024-12, Vol.89 (24), p.18436-18444
Main Authors: Rathod, Nileshkumar B., Patel, Raj N., Patel, Sachinkumar D., Patel, Dharmik M., Sonawane, Mahesh A., Thakur, Dinesh Gopichand, Ghosh, Subhash Chandra
Format: Article
Language:English
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Summary:A simple cobalt-catalyzed, picolinamide-directed C8–H sulfoxamination of 1-naphthalamides with NH-sulfoximines has been developed. This cross-dehydrogenative C–H/N–H coupling reaction offers a facile route to N-arylated sulfoximines, exhibiting high yields, a broad substrate scope, and excellent functional group tolerance and scalability.
ISSN:0022-3263
1520-6904
1520-6904
DOI:10.1021/acs.joc.4c02318