Monitoring the Interaction of Albumin with a Paclitaxel-Polymer Conjugate: Complex with Warfarin as Local Probe

We have used warfarin as a local probe to investigate the orientation of paclitaxel and water soluble polymer conjugates of paxlitaxel in albumin. The relative orientation of warfarin and paclitaxel in a 1:1 complex in solution was investigated by ¹H-NMR-spektroskopy (NOESY) and the results are used...

Full description

Saved in:
Bibliographic Details
Published in:Macromolecular symposia 2007-11, Vol.258 (1), p.101-107
Main Authors: Wunderlich, Stefan, Zähres, Manfred, Jo, Byung-Wook, Hess, Michael
Format: Article
Language:English
Subjects:
Albumins
Applied sciences
Biological and medical sciences
Conjugates
Exact sciences and technology
General pharmacology
interaction
Medical sciences
Monitoring
NMR
Organic polymers
Orientation
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Properties and characterization
proteins
Solution and gel properties
Summaries
Warfarin
Water soluble polymers
water-soluble drug conjugates
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have used warfarin as a local probe to investigate the orientation of paclitaxel and water soluble polymer conjugates of paxlitaxel in albumin. The relative orientation of warfarin and paclitaxel in a 1:1 complex in solution was investigated by ¹H-NMR-spektroskopy (NOESY) and the results are used for the interpretation of the steric situation of paclitaxel respectively the polymer conjugate in albumin.
ISSN:1022-1360
1521-3900
DOI:10.1002/masy.200751211