Monitoring the Interaction of Albumin with a Paclitaxel-Polymer Conjugate: Complex with Warfarin as Local Probe

We have used warfarin as a local probe to investigate the orientation of paclitaxel and water soluble polymer conjugates of paxlitaxel in albumin. The relative orientation of warfarin and paclitaxel in a 1:1 complex in solution was investigated by ¹H-NMR-spektroskopy (NOESY) and the results are used...

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Published in:Macromolecular symposia 2007-11, Vol.258 (1), p.101-107
Main Authors: Wunderlich, Stefan, Zähres, Manfred, Jo, Byung-Wook, Hess, Michael
Format: Article
Language:English
Subjects:
Albumins
Applied sciences
Biological and medical sciences
Conjugates
Exact sciences and technology
General pharmacology
interaction
Medical sciences
Monitoring
NMR
Organic polymers
Orientation
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Properties and characterization
proteins
Solution and gel properties
Summaries
Warfarin
Water soluble polymers
water-soluble drug conjugates
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cited_by cdi_FETCH-LOGICAL-c4451-4a0a2a3c2e2e47bf51099b47ce95aaef52174ac9b843146e7fdc52796e165f853
cites cdi_FETCH-LOGICAL-c4451-4a0a2a3c2e2e47bf51099b47ce95aaef52174ac9b843146e7fdc52796e165f853
container_end_page 107
container_issue 1
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container_title Macromolecular symposia
container_volume 258
creator Wunderlich, Stefan
Zähres, Manfred
Jo, Byung-Wook
Hess, Michael
description We have used warfarin as a local probe to investigate the orientation of paclitaxel and water soluble polymer conjugates of paxlitaxel in albumin. The relative orientation of warfarin and paclitaxel in a 1:1 complex in solution was investigated by ¹H-NMR-spektroskopy (NOESY) and the results are used for the interpretation of the steric situation of paclitaxel respectively the polymer conjugate in albumin.
doi_str_mv 10.1002/masy.200751211
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subjects Albumins
Applied sciences
Biological and medical sciences
Conjugates
Exact sciences and technology
General pharmacology
interaction
Medical sciences
Monitoring
NMR
Organic polymers
Orientation
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Properties and characterization
proteins
Solution and gel properties
Summaries
Warfarin
Water soluble polymers
water-soluble drug conjugates
title Monitoring the Interaction of Albumin with a Paclitaxel-Polymer Conjugate: Complex with Warfarin as Local Probe
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