Hypericum brasiliense: assessment of the antioxidant potential in UVA-induced in vitro phototoxicity

• Published in: Natural product research 2024-11, p.1-7
• Main Authors: Anacleto Dos Anjos, Raquel, Teixeira Araújo Gonçalves da Silva, Juliana, Mançano Class, Bruno, Oliveira da Silva, Lucas, Ferreira Leal, Lavinia, Bitler Delatorre Rosa, Sarah, Machado, Francisco Paiva, Seibert França, Hildegardo, Monte Alto Costa, Andréa, Rocha, Leandro Machado, Moreno Barbosa, Gleyce
• Format: Article
• Language: English
• ISSN: 1478-6419; 1478-6427; 1478-6427
• DOI: 10.1080/14786419.2024.2427808

Photoaging induced by ultraviolet A (UVA) radiation is mainly caused by the reactive oxygen species (ROS) increase, which trigger undesirable changes in the skin, such as inflammatory reactions, wrinkles, hyperpigmentation, and loss of elasticity. In this context, plant ingredients have been highlighted in recent decades due to their antioxidant mechanisms. This study investigated the potential of ethanolic extract against UVA-induced damage in 3T3 fibroblasts. Cells exposed to a single UVA dose (4 J/cm , 30 min) were treated with different extract concentrations. The results showed that extract has antioxidant potential, mitigating UVA-induced stress by reducing ROS and lipid peroxidation. Furthermore, the extract stimulated fibroblast proliferation, suggesting its potential to restore cell viability after radiation-induced damage. The search for replacing synthetic actives with natural ones reinforces the importance of these findings on the antioxidant and regenerative properties of extract, making it a promising anti-aging ingredient or a sunscreen adjuvant.