The role of vitamin D metabolism in regulating bone turnover in adolescents with perinatally-acquired HIV in southern Africa: a cross-sectional study in Zimbabwe and Zambia

Vitamin D dysregulation can occur in people living with HIV, disrupting calcium homeostasis and bone turnover. We aimed to investigate the potential mechanisms by which vitamin D regulates bone turnover in adolescents living with perinatally-acquired HIV (ALWH) in southern Africa. A pre-planned seco...

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Published in:Journal of bone and mineral research 2024-11
Main Authors: Madanhire, Tafadzwa, Ward, Kate A, Macdougall, Amy, Mohammed, Nuredin, Filteau, Suzanne, Kasonka, Lackson, Mabuda, Hilda B, Chisenga, Molly, Tang, Jonathan, Fraser, William D, Bandason, Tsitsi, Dzavakwa, Nyasha V, Simms, Victoria, Ferrand, Rashida A, Gregson, Celia L
Format: Article
Language:English
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Summary:Vitamin D dysregulation can occur in people living with HIV, disrupting calcium homeostasis and bone turnover. We aimed to investigate the potential mechanisms by which vitamin D regulates bone turnover in adolescents living with perinatally-acquired HIV (ALWH) in southern Africa. A pre-planned secondary analysis was performed of baseline data from the VITALITY trial [PACTR20200989766029] which enrolled ALWH (11-19 years) taking antiretroviral therapy for ≥6 months, and recorded socio-demographic, clinical and dietary data. After over-night fasting, vitamin D metabolites [25(OH)D, 1,25(OH)2D, 24,25(OH)2D], intact parathyroid hormone (PTH) and bone turnover markers (BTMs) [CTX and P1NP] were measured. Tandem Mass Spectrometry measured vitamin D metabolites, whilst intact PTH and BTMs were analysed by electrochemiluminescence immunoassay. Stratified by 25(OH)D [
ISSN:0884-0431
1523-4681
1523-4681
DOI:10.1093/jbmr/zjae190