State-level disparities in cervical cancer prevention and outcomes in the U.S.: a modeling study

Despite HPV vaccines' availability for over a decade, coverage across the US varies. While some states have tried to increase HPV vaccination coverage, most model-based analyses focus on national impacts. We evaluated hypothetical changes in HPV vaccination coverage at the national and state le...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 2024-11
Main Authors: Alarid-Escudero, Fernando, Gracia, Valeria, Wolf, Marina, Zhao, Ran, Easterly, Caleb W, Kim, Jane J, Canfell, Karen, de Kok, Inge M C M, Barnabas, Ruanne V, Kulasingam, Shalini
Format: Article
Language:English
Online Access:Get full text
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Summary:Despite HPV vaccines' availability for over a decade, coverage across the US varies. While some states have tried to increase HPV vaccination coverage, most model-based analyses focus on national impacts. We evaluated hypothetical changes in HPV vaccination coverage at the national and state levels for California, New York, and Texas using a mathematical model. We developed a new mathematical model of HPV transmission and cervical cancer, creating US and state-level models, incorporating country- and state-specific vaccination coverage and cervical cancer incidence and mortality. We quantified the national and state-level impact of increasing HPV vaccination coverage to 80% by 2025 or 2030 on cervical cancer outcomes and the time to elimination defined as 
ISSN:0027-8874
1460-2105
1460-2105
DOI:10.1093/jnci/djae298