Organoid models of breast cancer in precision medicine and translational research

One of the most famous and heterogeneous cancers worldwide is breast cancer (BC). Owing to differences in the gene expression profiles and clinical features of distinct BC subtypes, different treatments are prescribed for patients. However, even with more thorough pathological evaluations of tumors...

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Bibliographic Details
Published in:Molecular biology reports 2025-12, Vol.52 (1), p.2, Article 2
Main Authors: Niazi, Vahid, Parseh, Benyamin
Format: Article
Language:English
Subjects:
Animal Anatomy
Animal Biochemistry
Animals
Biomedical and Life Sciences
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Cancer therapies
Chemotherapy
Classification
Clinical outcomes
Drug screening
Epidermal growth factor
Female
Gene expression
Histology
Humans
Immunotherapy
Immunotherapy - methods
Kinases
Life Sciences
Medical prognosis
Medical research
Molecular biology
Morphology
Organoids
Organoids - drug effects
Organoids - pathology
Patients
Penicillin
Physical characteristics
Precision medicine
Precision Medicine - methods
Review
Translation
Translational Research, Biomedical - methods
Tumors
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Summary:One of the most famous and heterogeneous cancers worldwide is breast cancer (BC). Owing to differences in the gene expression profiles and clinical features of distinct BC subtypes, different treatments are prescribed for patients. However, even with more thorough pathological evaluations of tumors than in the past, available treatments do not perform equally well for all individuals. Precision medicine is a new approach that considers the effects of patients’ genes, lifestyle, and environment to choose the right treatment for an individual patient. As a powerful tool, the organoid culture system can maintain the morphological and genetic characteristics of patients’ tumors. Evidence also shows that organoids have high predictive value for patient treatment. In this review, a variety of BC studies performed on organoid culture systems are evaluated. Additionally, the potential of using organoid models in BC translational research, especially in immunotherapy, drug screening, and precision medicine, has been reported.
ISSN:0301-4851
1573-4978
1573-4978
DOI:10.1007/s11033-024-10101-x