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Organoid models of breast cancer in precision medicine and translational research
One of the most famous and heterogeneous cancers worldwide is breast cancer (BC). Owing to differences in the gene expression profiles and clinical features of distinct BC subtypes, different treatments are prescribed for patients. However, even with more thorough pathological evaluations of tumors...
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| Published in: | Molecular biology reports 2025-12, Vol.52 (1), p.2, Article 2 |
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| creator | Niazi, Vahid Parseh, Benyamin |
| description | One of the most famous and heterogeneous cancers worldwide is breast cancer (BC). Owing to differences in the gene expression profiles and clinical features of distinct BC subtypes, different treatments are prescribed for patients. However, even with more thorough pathological evaluations of tumors than in the past, available treatments do not perform equally well for all individuals. Precision medicine is a new approach that considers the effects of patients’ genes, lifestyle, and environment to choose the right treatment for an individual patient. As a powerful tool, the organoid culture system can maintain the morphological and genetic characteristics of patients’ tumors. Evidence also shows that organoids have high predictive value for patient treatment. In this review, a variety of BC studies performed on organoid culture systems are evaluated. Additionally, the potential of using organoid models in BC translational research, especially in immunotherapy, drug screening, and precision medicine, has been reported. |
| doi_str_mv | 10.1007/s11033-024-10101-x |
| format | article |
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Owing to differences in the gene expression profiles and clinical features of distinct BC subtypes, different treatments are prescribed for patients. However, even with more thorough pathological evaluations of tumors than in the past, available treatments do not perform equally well for all individuals. Precision medicine is a new approach that considers the effects of patients’ genes, lifestyle, and environment to choose the right treatment for an individual patient. As a powerful tool, the organoid culture system can maintain the morphological and genetic characteristics of patients’ tumors. Evidence also shows that organoids have high predictive value for patient treatment. In this review, a variety of BC studies performed on organoid culture systems are evaluated. 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Parseh, Benyamin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-5c1dc8db6e49930c54fdc91c9bb9912c5acc6795655824675303b128dff6ae6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Classification</topic><topic>Clinical outcomes</topic><topic>Drug screening</topic><topic>Epidermal growth factor</topic><topic>Female</topic><topic>Gene expression</topic><topic>Histology</topic><topic>Humans</topic><topic>Immunotherapy</topic><topic>Immunotherapy - methods</topic><topic>Kinases</topic><topic>Life Sciences</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Molecular biology</topic><topic>Morphology</topic><topic>Organoids</topic><topic>Organoids - drug effects</topic><topic>Organoids - pathology</topic><topic>Patients</topic><topic>Penicillin</topic><topic>Physical characteristics</topic><topic>Precision medicine</topic><topic>Precision Medicine - methods</topic><topic>Review</topic><topic>Translation</topic><topic>Translational Research, Biomedical - methods</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Niazi, Vahid</creatorcontrib><creatorcontrib>Parseh, Benyamin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Niazi, Vahid</au><au>Parseh, Benyamin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Organoid models of breast cancer in precision medicine and translational research</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2025-12-01</date><risdate>2025</risdate><volume>52</volume><issue>1</issue><spage>2</spage><pages>2-</pages><artnum>2</artnum><issn>0301-4851</issn><issn>1573-4978</issn><eissn>1573-4978</eissn><abstract>One of the most famous and heterogeneous cancers worldwide is breast cancer (BC). 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| subjects | Animal Anatomy Animal Biochemistry Animals Biomedical and Life Sciences Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer therapies Chemotherapy Classification Clinical outcomes Drug screening Epidermal growth factor Female Gene expression Histology Humans Immunotherapy Immunotherapy - methods Kinases Life Sciences Medical prognosis Medical research Molecular biology Morphology Organoids Organoids - drug effects Organoids - pathology Patients Penicillin Physical characteristics Precision medicine Precision Medicine - methods Review Translation Translational Research, Biomedical - methods Tumors |
| title | Organoid models of breast cancer in precision medicine and translational research |
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