Inflammatory Waldenström macroglobulinemia is associated with clonal hematopoiesis: a multicentric cohort

Inflammatory form of Waldenström macroglobulinemia (iWM) predicts outcomes after immuno-chemotherapy and Bruton tyrosine kinase inhibitors, but its origin is unknown. Here, we unravel increased clonal hematopoiesis in patients with iWM (61% vs 23% in noninflammatory WM), suggesting a contribution of...

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Published in:Blood 2024-11
Main Authors: Debureaux, Pierre-Edouard, Poulain, Stéphanie, Harel, Stéphanie, Passet, Marie, Templé, Marie, Friedrich, Chloé, Forgeard, Nathalie, Elessa, Dikelele, Plas, William, Chat, Laureen, Lazarian, Grégory, Willems, Lise, Royer, Bruno, Talbot, Alexis, Vaugeois, Tristan, Theves, Floriane, Terré, Alexandre, Brignier, Anne, Malphettes, Marion, Krzisch, Daphné, Frenzel, Laurent, Davi, Frédéric, Bravetti, Clotilde, Nguyen-Khac, Florence, Dupuis, Jehan, Cuccuini, Wendy, Bouscary, Didier, Hermine, Olivier, Roos-Weil, Damien, Kosmider, Olivier, Clappier, Emmanuelle, Espéli, Marion, Balabanian, Karl, Arnulf, Bertrand
Format: Article
Language:English
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Summary:Inflammatory form of Waldenström macroglobulinemia (iWM) predicts outcomes after immuno-chemotherapy and Bruton tyrosine kinase inhibitors, but its origin is unknown. Here, we unravel increased clonal hematopoiesis in patients with iWM (61% vs 23% in noninflammatory WM), suggesting a contribution of environmental cells to iWM.
ISSN:0006-4971
1528-0020
1528-0020
DOI:10.1182/blood.2024025738