Epstein-Barr virus-associated B-cell lymphoproliferative disorders and lymphomas: Diagnostic overlaps and defining features

This review explores four Epstein-Barr virus (EBV)-associated B-cell lymphoproliferative disorders (LPD) and lymphomas with significant diagnostic overlap: EBV(+) mucocutaneous ulcer (EBVMCU), EBV(+) polymorphic LPD, EBV(+) classic Hodgkin lymphoma (CHL), and EBV(+) diffuse large B-cell lymphoma (DL...

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Bibliographic Details
Published in:Human pathology 2024-11, p.105697, Article 105697
Main Authors: Volaric, Ashley K., Fedoriw, Yuri
Format: Article
Language:English
Subjects:
B-Cell lymphoma
B-Cell lymphoproliferative disorder
Classic Hodgkin lymphoma
Diffuse large B-Cell lymphoma
EBV
Epstein-Barr virus
Immunodeficiency
Mucocutaneous ulcer
Polymorphic B-Cell lymphoproliferative disorder
Post-transplant
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Summary:This review explores four Epstein-Barr virus (EBV)-associated B-cell lymphoproliferative disorders (LPD) and lymphomas with significant diagnostic overlap: EBV(+) mucocutaneous ulcer (EBVMCU), EBV(+) polymorphic LPD, EBV(+) classic Hodgkin lymphoma (CHL), and EBV(+) diffuse large B-cell lymphoma (DLBCL). Each entity is compared for both overlapping and defining features of clinical presentation, morphology, immunohistochemical profile and EBV expression pattern and latency. Our aims for this review are to provide useful guidance to the practicing pathologist in the diagnosis of these EBV-associated entities.
ISSN:0046-8177
1532-8392
1532-8392
DOI:10.1016/j.humpath.2024.105697