Continued attention: The role of exosomal long non-coding RNAs in tumors over the past three years

•Exosomal long non-coding RNAs have the potential to influence various cell, the extracellular matrix, and metabolism.•The impact of exosomal long non-coding RNAs on tumors may exhibit bidirectional effects.•Exosomal long non-coding RNAs represents a novel strategy for both diagnosis and treatment.•...

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Published in:International immunopharmacology 2025-01, Vol.144, p.113666, Article 113666
Main Authors: Cao, Jiarui, Feng, Bo, Xv, Yanchao, Yu, Jiangfan, Cao, Shasha, Ma, Chunzheng
Format: Article
Language:English
Subjects:
Animals
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Drug resistance
Epithelial-Mesenchymal Transition - genetics
Exosomes
Exosomes - genetics
Exosomes - metabolism
Humans
Immune cells
Long non-coding RNA
Metabolism
Microenvironment
Neoplasms - genetics
Neoplasms - immunology
Neoplasms - metabolism
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Tumor Microenvironment - genetics
Tumor Microenvironment - immunology
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Summary:•Exosomal long non-coding RNAs have the potential to influence various cell, the extracellular matrix, and metabolism.•The impact of exosomal long non-coding RNAs on tumors may exhibit bidirectional effects.•Exosomal long non-coding RNAs represents a novel strategy for both diagnosis and treatment.•This article summarizes the recurrence of exosomal long non-coding RNAs over the past three years and their mechanisms. This review summarizes the research on exosomal lncRNAs in tumors over the past three years. It highlights the significant roles of exosomal lncRNAs in modulating various cellular processes within the tumor microenvironment. Exosomal lncRNAs have been shown to influence the behavior of tumor cells, promoting proliferation, metastasis, epithelial-mesenchymal transition (EMT), angiogenesis, glycolysis, and contributing to tumor growth and metabolism. Moreover, exosomal lncRNAs have been found to interact with immune cells, such as modulating the functions of macrophages and influencing the overall immune response against tumors. Fibroblasts within the tumor microenvironment are also affected by exosomal lncRNAs, which can alter the extracellular matrix (ECM) and stromal composition. Notably, these exosomal lncRNAs hold promise in the diagnosis and treatment of tumors, offering potential biomarkers and therapeutic targets for improved clinical outcomes.
ISSN:1567-5769
1878-1705
1878-1705
DOI:10.1016/j.intimp.2024.113666