Intensive Blood Pressure Lowering in Acute Stroke with Intracranial Stenosis Post-Thrombectomy: a secondary analysis of the OPTIMAL-BP trial

• Published in: International journal of stroke 2024-11, p.17474930241305315
• Main Authors: Kim, Kwang Hyun, Yun, Jaeseob, Jung, Jae Wook, Kim, Young Dae, Heo, JoonNyung, Lee, Hyungwoo, Choi, Jin Kyo, Lee, Il Hyung, Lim, In Hwan, Hong, Soon-Ho, Baik, Minyoul, Kim, Byung Moon, Kim, Dong Joon, Shin, Na Young, Cho, Bang-Hoon, Ahn, Seong Hwan, Park, Hyungjong, Sohn, Sung-Il, Hong, Jeong-Ho, Song, Tae-Jin, Chang, Yoonkyung, Kim, Gyu Sik, Seo, Kwon-Duk, Lee, Kijeong, Chang, Jun Young, Seo, Jung Hwa, Lee, Sukyoon, Baek, Jang-Hyun, Cho, Han-Jin, Shin, Dong Hoon, Kim, Jinkwon, Yoo, Joonsang, Lee, Kyung Yul, Jung, Yo Han, Hwang, Yang-Ha, Kim, Chi Kyung, Kim, Jae Guk, Lee, Chan Joo, Park, Sungha, Lee, Hye Sun, Kwon, Sun U, Bang, Oh Young, Heo, Ji Hoe, Nam, Hyo Suk
• Format: Article
• Language: English
• ISSN: 1747-4930; 1747-4949; 1747-4949
• DOI: 10.1177/17474930241305315

Intensive blood pressure (BP) management within 24 hours after successful reperfusion following endovascular thrombectomy (EVT) is associated with worse functional outcomes than conventional BP management in Asian randomized controlled trials. Given the high prevalence of intracranial atherosclerotic stenosis (ICAS) in Asia, ICAS may influence these outcomes. We aimed to assess whether ICAS affects the outcomes of intensive BP management after successful EVT. We conducted a secondary analysis of the Outcome in Patients Treated With Intra-Arterial Thrombectomy-Optimal Blood Pressure Control trial, which enrolled participants from June 2020 to November 2022. Patients with anterior circulation large vessel occlusion (LVO) were stratified into ICAS-related and embolic LVO groups. Clinical outcomes for intensive (target systolic BP