Expression of Immunohistochemical Markers in the Walls of Pelvic Varicose Veins in Women

The tissue preparations of the pelvic veins obtained during laparoscopy were examined. The expression of markers of proliferation (Ki-67), apoptosis (p53), and angiogenesis (CD31, CD34), as well as estrogen and progesterone receptors in women with pelvic varicose veins was assessed by the immunohist...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2024-11, Vol.178 (1), p.151-156
Main Authors: Darenskaya, M. A., Semendyaev, A. A., Stupin, D. A., Kolesnikov, S. I., Semenova, N. V., Tukhieva, D. V., Shcherbatykh, A. V., Kolesnikova, L. I.
Format: Article
Language:English
Subjects:
Adult
Age
Angiogenesis
Antigens, CD34 - metabolism
Apoptosis
Biomarkers - metabolism
Biomedical and Life Sciences
Biomedicine
Biopsy
CD34 antigen
Cell Biology
Cell cycle
Chronic illnesses
Consent
Estrogens
Female
Humans
Immunohistochemistry
Infertility
Internal Medicine
Ki-67 Antigen - genetics
Ki-67 Antigen - metabolism
Laboratory Medicine
Laparoscopy
Middle Aged
Neovascularization, Pathologic - metabolism
Neovascularization, Pathologic - pathology
Ovaries
p53 Protein
Pathology
Pelvis - blood supply
Platelet Endothelial Cell Adhesion Molecule-1 - metabolism
Progesterone
Progesterone receptors
Receptors, Estrogen - genetics
Receptors, Estrogen - metabolism
Receptors, Progesterone - metabolism
Smooth muscle
Steroids
Tumor Suppressor Protein p53 - metabolism
Varicose veins
Varicose Veins - metabolism
Varicose Veins - pathology
Veins
Womens health
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Description
Summary:The tissue preparations of the pelvic veins obtained during laparoscopy were examined. The expression of markers of proliferation (Ki-67), apoptosis (p53), and angiogenesis (CD31, CD34), as well as estrogen and progesterone receptors in women with pelvic varicose veins was assessed by the immunohistochemical method. A decrease in the median expression of the proliferation marker (Ki-67) and estrogen and progesterone receptors and simultaneous increase in the expression of apoptosis marker (p53) and activation of angiogenesis processes (markers CD31 and CD34) were observed with increasing the severity of the disease. These data extend our understanding of the pathogenetic mechanisms of pelvic varicose veins and contribute to the development of methods of pathogenetically based targeted therapy.
ISSN:0007-4888
1573-8221
1573-8221
DOI:10.1007/s10517-024-06298-3