Solitary Fibrous Tumor of the Mandible

A 41-year-old woman presented with a facial asymmetry in the mental region and a painful, well-circumscribed, tender mass in the right lower buccal vestibule, associated with extensive ill-defined bone rarefaction with subtle cortical bone resorption. Microscopically, a proliferation of bland spindl...

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Bibliographic Details
Published in:Head & neck pathology (Totowa, N.J.) N.J.), 2024-11, Vol.18 (1), p.124, Article 124
Main Authors: Fonsêca, Thamyres Campos, Agostini, Michelle, Paes, Jefferson Viapiana, Roza, Ana Luiza Oliveira Corrêa, van Heerden, Willie F.P., Romañach, Mário José, Abrahão, Aline Corrêa
Format: Article
Language:English
Subjects:
Adult
Biomarkers, Tumor - analysis
Dentistry
Female
Humans
Mandibular Neoplasms - pathology
Medicine
Medicine & Public Health
Oral and Maxillofacial Surgery
Otorhinolaryngology
Pathology
Solitary Fibrous Tumors - pathology
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Summary:A 41-year-old woman presented with a facial asymmetry in the mental region and a painful, well-circumscribed, tender mass in the right lower buccal vestibule, associated with extensive ill-defined bone rarefaction with subtle cortical bone resorption. Microscopically, a proliferation of bland spindle cells interspersed with collagen fibers and prominent staghorn-like blood vessels was observed. Immunohistochemical analysis revealed strong positivity for CD34, Bcl-2, CD99, and STAT-6, confirming the diagnosis of Solitary Fibrous Tumor (SFT). Conservative surgical enucleation was performed, and 4 years later, recurrence was observed with extensive bone involvement and moth-eaten margins resembling a malignant tumor. SFT is a distinctive spindle cell tumor of fibroblastic differentiation, characterized by prominent branching staghorn-like vessels and a specific NAB2::STAT6 gene fusion. We herein contribute with a central SFT of the mandible with recurrent behavior and radiographic appearance suggesting malignancy.
ISSN:1936-0568
1936-0568
DOI:10.1007/s12105-024-01731-5