Leukocyte-lymphatic intersections during cardiac inflammation

Advances in genetic, pharmacologic, and sequencing technology have led to new insight into the role of lymphatics in health and disease. This includes fundamental aspects of the crosstalk between immune cells with cardiac lymphatics. At the interface between leukocytes and lymphatic endothelial cell...

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Bibliographic Details
Published in:Journal of molecular and cellular cardiology 2025-01, Vol.198, p.13-20
Main Authors: Glinton, Kristofor, Thakkar, Abhishek V., Jones, Rebecca, Inui, Hiroyasu, Ge, Zhi-Dong, Thorp, Edward B.
Format: Article
Language:English
Subjects:
Lymphatic endothelial cell
Macrophage
Myocardial infarction
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Summary:Advances in genetic, pharmacologic, and sequencing technology have led to new insight into the role of lymphatics in health and disease. This includes fundamental aspects of the crosstalk between immune cells with cardiac lymphatics. At the interface between leukocytes and lymphatic endothelial cells, myeloid populations are sources of lymphatic growth factors during inflammation. Lymphatic endothelial cells also secrete signals that activate leukocytes, including to antigen presenting cells. Taken together, a view of the lymphatic vasculature as a supplemental cardiac immune hub is emerging. Herein, we discuss reciprocal cell and molecular crosstalk between leukocytes and lymphatics in the myocardium, with implications for health and cardiac inflammation. •Cardiac lymphatics interact closely with immune cells during organ development•Lymphatics can promote inflammation resolution.•Cardiac lymphatics respond and direct singals to leukocytes.
ISSN:0022-2828
1095-8584
1095-8584
DOI:10.1016/j.yjmcc.2024.11.006