Measuring the effects of ketogenic diet on neuropsychiatric disorder: A scoping review

• Published in: Progress in neuro-psychopharmacology & biological psychiatry 2025-01, Vol.136, p.111205, Article 111205
• Main Authors: Yousufzai, Wali, Singh, Monika, Ahmadi, Leeda, Balamurali, Shreya, Bavishi, Divyaraj, Ashraf, Sahar, Stuart, Daniel B., Baronia, Regina, Amor, Wail
• Format: Article
• Language: English
• Subjects: Anxiety disorder; Autism; Cognitive impairment; Depressive disorder; Eating disorder; Epilepsy; Ketogenic diet; Neuropsychiatric disorder; Parkinson's disease
• ISSN: 0278-5846; 1878-4216; 1878-4216
• DOI: 10.1016/j.pnpbp.2024.111205

Objective: This scoping review aims to examine the available literature on the ketogenic diet's (KD) efficiency as a potential therapeutic intervention for various neuropsychiatric disorders. Introduction: The KD is a high-fat, low-carbohydrate diet that has been studied for its potential benefits in managing neuropsychiatric disorders. However, the extent of its effectiveness across a spectrum of these conditions remains unclear. Inclusion criteria: The study designs considered eligible encompassed randomized and non-randomized controlled trials, retrospective and prospective observational studies, and comparative effectiveness assessments. The criteria for including each study were specifically related to neuropsychiatric disorders, referring to the DSM-5 coding guidelines. Methods: A systemic search was performed by an experienced reference librarian across multiple databases to pinpoint studies relevant to the influence of the ketogenic diet on neuropsychiatric disorders. All relevant articles were included that ranged over the last thirteen years. All relevant records identified were compiled into the Covidence systematic review software. Results: A total of 30 studies were reviewed, which reported effects of the KD on neuropsychiatric disorders, including improvements in Global Developmental Delay, Childhood Autism, Attention Deficit/Hyperactivity Disorder (ADHD) symptoms, psychotic symptoms, Bipolar and Related Disorders, Depressive Disorder symptoms, anxiety symptoms, eating disorders, Substance-Related and Addictive Disorders, Major and Mild Neurocognitive Disorders, and Seizure Disorders. Conclusion: The KD may serve as a promising therapeutic intervention for various neuropsychiatric disorders. However, the evidence is heterogeneous, and further rigorous research is needed to establish the KD as a standard treatment for these disorders and to understand the underlying mechanisms of its effects. Implications for Practice: This review underscores the need for healthcare professionals to consider the potential benefits and limitations of the KD when managing patients with neuropsychiatric disorders. It also highlights the importance of individualized treatment plans based on the specific needs and responses of each patient. •This scoping review examines the ketogenic diet (KD) as a potential therapeutic intervention for various neuropsychiatric disorders.•A thorough systematic search identified 30 studies over the past thirteen years, assessing KD'