Efficacy of high-flow nasal oxygenation during induction of general anaesthesia in parturients living with obesity: a two-centre, prospective, randomised clinical trial

• Published in: Anaesthesia 2024-11
• Main Authors: Zhou, Shuang-Qiong, Lian, Jian-Feng, Zhou, Yao, Cao, Xiu-Hong, Ni, Xiu, Zhang, Xiao-Peng, Xu, Zhen-Dong, Xiao, Quan-Sheng, Liu, Zhi-Qiang
• Format: Article
• Language: English
• ISSN: 0003-2409; 1365-2044; 1365-2044
• DOI: 10.1111/anae.16492

High-flow nasal oxygenation has been shown to improve oxygenation during induction of anaesthesia in parturients who are not obese. However, data on the efficacy of high-flow nasal oxygen in parturients living with obesity are lacking. This study investigated the effects of high-flow nasal oxygenation on pre-oxygenation and apnoea oxygenation during tracheal intubation in parturients living with obesity. This prospective, randomised clinical trial was conducted at two tertiary hospitals and included parturients with BMI > 30 kg.m undergoing scheduled caesarean delivery under general anaesthesia. Parturients were allocated randomly to standard facemask or high-flow nasal oxygen groups (oxygen flow rates 10 l.min and 50 l.min , respectively). The primary outcome measure was arterial partial pressure of oxygen after 3 min of pre-oxygenation. 54 patients completed the study. The arterial partial pressure of oxygen after 3 min of pre-oxygenation was significantly lower in parturients allocated to the standard facemask group compared with those allocated to the high-flow nasal oxygen group (mean (SD) 40.1 (8.9) kPa vs. 53.8 (9.7) kPa, p